沙库巴曲缬沙坦治疗原发性高血压的可行性分析  

Sakubatril-valsartan for treating essential hypertension:a feasibility analysis

作　　者：熊海亮 胡凤英 黄安静 贾春新 张天铧 张英 Xiong Hailiang;Hu Feng ying;Huang Anjing;Jia Chunxin;Zhang Tianhua;Zhang Ying(Department of Cardiovascular Medicine,Tangshan Central Hospital,Tangshan 063000,China;不详)

机构地区：[1]唐山中心医院心血管内科,唐山063000

出　　处：《中国循证心血管医学杂志》2024年第4期433-435,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：河北省医学科学研究课题计划(20221849)。

摘　　要：目的探讨沙库巴曲缬沙坦对原发性高血压患者交感神经活性、血管内皮功能的影响。方法选取2021年7月至2022年6月于唐山中心医院收治的120例高血压患者为研究对象,采用随机数字表法分为对照组与研究组,每组各60例。对照组采用氨氯地平治疗,治疗初始服用剂量5 mg,qd,最大剂量为10 mg。连续服用1周后,根据患者情况调整剂量。研究组在对照组基础上加用沙库巴曲缬沙坦治疗50 mg,bid。对比两组患者血压水平[收缩压(SBP)、舒张压(DBP)]、交感神经活性水平[肾上腺素(E)、肾素活性(PRA)、去甲肾上腺素(NE)、血管紧张素Ⅱ(AngⅡ)]、一氧化氮(NO)、血管内皮素-1(ET-1)以及不良反应发生情况。结果治疗后,研究组患者SBP、DBP均高于对照组,差异有统计学意义(P<0.05);治疗后两组NE、E、PRA、AngⅡ均降低,研究组水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组患者NO、ET-1均升高,研究组水平高于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率相比,差异无统计学意义(P>0.05)。结论沙库巴曲缬沙坦应用于原发性高血压患者的治疗疗效显著,可降低交感神经活性、改善血管内皮功能。Objective To discuss the influence of sakubatril-valsartan on sympathetic nerve activity and vascular endothelial function in patients with essential hypertension(EH).Methods EH patients(n=120)were chosen from Tangshan Central Hospital from July 2021 to June 2022,and divided,according to random digital table,into control group and study group(each n=60).The control group was treated with amlodipine,with an initial dose of 5 mg/d,up to a maximum of 10 mg.After one week of continuous administration,the dosage was adjusted based on the patients’conditions.The study group was additionally treated with sakubatril-valsartan,with a dosage of 50 mg twice daily.The levels of blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP)],sympathetic nerve activity[epinephrine(E),plasma renin activity(PRA),noradrenalin(NE),angiotensinⅡ(AngⅡ)],nitric oxide(NO)and endothelin-1(ET-1),and adverse reactions were compared between 2 groups.Results After treatment,levels of SBP and DBP were higher in study group than those in control group(P<0.05),levels of NE,E,PRA and AngⅡdecreased in 2 groups,and were lower in study group than those in control group(P<0.05),and levels of NO and ET-1 increased,and were higher in study group than those in control group(P<0.05).The difference in incidence of adverse reactions had no statistical significance between 2 groups(P>0.05).Conclusion The curative effect of sakubatril-valsartan is significant in EH patients,which can reduce sympathetic nerve activity and improve vascular endothelial function.

关 键 词：原发性高血压 沙库巴曲缬沙坦 交感神经活性 血管内皮功能 

分 类 号：R544.1[医药卫生—心血管疾病]