血清miR-31在主动脉狭窄致心肌肥厚患者中的作用价值  

Value of serum microRNA-31 in patients with myocardial hypertrophy induced by aortic stenosis

作　　者：郭芳[1] 杨建中[1] 蔡新妤 Guo Fang;Yang Jianzhong;Cai Xinyu(Comprehensive Emergency Ward,Emergency Trauma Center,First Affiliated Hospital of Xinjiang Medical University,Urumchi 830000,China;不详)

机构地区：[1]新疆医科大学第一附属医院急救创伤中心急诊综合病房,乌鲁木齐830000

出　　处：《中国循证心血管医学杂志》2024年第4期481-483,489,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探究血清microRNA-31(miR-31)在主动脉狭窄致心肌肥厚患者中的作用。方法选取2020年1月至2020年10月就诊于新疆医科大学第一附属医院的主动脉狭窄致心肌肥厚患者150例为观察组,并选取同期健康志愿者150例为对照组,比较两组患者miR-31、舒张末期左心室后壁厚度(LVPWTd)、室间隔舒张末期厚度(IVSTd)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)和左心室重量指数(LVMI)。同时对150例主动脉狭窄致心肌肥厚患者进行随访3年,观察其是否发生不良心血管事件,分析miR-31对不良心血管事件的预测价值。结果与对照组比较,观察组miR-31显著增加(1.25±0.26 vs.0.71±0.23,P<0.001)。血清miR-31与主动脉狭窄致心肌肥厚患者LVPWTd、IVSTd、LVEDD、LVMI均呈显著正相关(r=0.372、0.401、0.362和0.452,P<0.05),而与LVEF呈显著负相关(r=-0.317,P=0.010)。对150例主动脉狭窄致心肌肥厚患者随访3年发现,与未发生不良心血管事件的患者相比,发生不良心血管事件的患者血清miR-31显著增加(1.44±0.17 vs.1.21±0.26,P<0.001)。血清miR-31对主动脉狭窄致心肌肥厚患者不良心血管事件具有较好的预测价值,曲线下面积0.752(95%CI:0.668~0.837,P<0.001)。结论血清miR-31在主动脉狭窄致心肌肥厚患者中可能具有重要潜力,是主动脉狭窄致心肌肥厚的潜在生物学指标。Objective To investigate the effect of serum microRNA-31(miR-31)in patients with myocardial hypertrophy induced by aortic stenosis.Methods The patients with myocardial hypertrophy induced by aortic stenosis were chosen into observation group and healthy volunteers were chosen into control group(each n=150)from the First Affiliated Hospital of Xinjiang Medical University from Jan.2020 to Oct.2020.The indexes of miR-31,left ventricular posterior wall thickness at end diastole(LVPWTd),interventricular septum thickness of enddiastole(IVSTd),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)and left ventricular mass index(LVMI)were compared between 2 groups.The observation was followed up for 3 y to observe the occurrence of major adverse cardiovascular events(MACE),and analyze the predictive value of miR-31 to MACE.Results The level of serum miR-31 increased significantly in observation group compared with control group(1.25±0.26 vs.0.71±0.23,P<0.001).The level of serum miR-31 was positively correlated to levels of LVPWTd,IVSTD,LVEDD and LVMI(r=0.372,0.401,0.362,0.452,P<0.05),and negatively correlated to LVEF(r=-0.317,P=0.010)in observation group.After followed up in patients with myocardial hypertrophy induced by aortic stenosis for 3 y,the level of serum miR-31 increased significantly in MACE patients compared with non-MACE patients(1.44±0.17 vs.1.21±0.26,P<0.001).The level of serum miR-31 had a higher predictive value to MACE,and AUC was 0.752(95%CI:0.668~0.837,P<0.001)in patients with myocardial hypertrophy induced by aortic stenosis.Conclusion The level of serum miR-31 may have important potential in patients with myocardial hypertrophy induced by aortic stenosis,and is a potential biological indicator of myocardial hypertrophy induced by aortic stenosis.

关 键 词：主动脉狭窄 心肌肥厚 miR-31 

分 类 号：R543.13[医药卫生—心血管疾病]