基于质量控制状况、临床应用及网络药理学的天麻质量标志物预测分析  

Predictive analysis on quality markers of Gastrodiae Rhizoma based on quality control status,clinical application and network pharmacology

作　　者：祁昱彤 孟硕[1] 彭勍[1] 任钧国[1] 张淼[1] 刘建勋[1] QI Yu-tong;MENG Shuo;PENG Qing;REN Jun-guo;ZHANG Miao;LIU Jian-xun(Beijing Key Laboratory of Pharmacology of Chinese Materia Medica,Institute of Basic Medical Sciences of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院基础医学研究所/中药药理北京市重点研究室,北京100091

出　　处：《中国新药杂志》2024年第13期1329-1338,共10页Chinese Journal of New Drugs

基　　金：中国中医科学院科技创新工程重大攻关项目(CI2021A04310);中国中医科学院科技创新工程重大攻关项目(CI2021A05022)。

摘　　要：天麻是息风止痉类代表中药,药用历史悠久。临床上以天麻为君药的复方不胜枚举,疗效十分广泛。然而现行质量标准仅以天麻素和对羟基苯甲醇2个指标的含量来评价天麻品质的优劣,并不十分科学,且已经不能满足中药天麻的进一步开发和利用。本文对天麻质量控制状况及临床应用进行综述,基于中药质量标志物(quality marker,Q-marker)理论,从传统药性及药效、特有化学成分、网络药理学等角度对天麻进行Q-marker初步预测分析,为天麻质量控制提供科学依据。Gastrodiae Rhizoma is a representative traditional Chinese medicine with a long history of medicinal use.Clinically,there are many formulas taking Gastrodiae Rhizoma as one principal medicine,and exerting extensive pharmacological effects.However,the current quality standards of Gastrodiae Rhizoma are only evaluated based on the contents of gastrodin and p-hydroxybenzyl methanol,which are not very scientific and can no longer meet the further development and utilization of Gastrodiae Rhizoma.Quality control status and main clinical application of Gastrodiae Rhizoma were summarized in this paper based on quality marker(Q-marker)theory of traditional Chinese medicine.The preliminary Q-markers prediction analysis of Gastrodiae Rhizoma was carried out from the perspectives of traditional medicinal properties and efficacy,unique chemical composition,and network pharmacology,so as to provide a scientific basis for the quality control of Gastrodiae Rhizoma.

关 键 词：天麻 质量控制 网络药理学 质量标志物 酚酸类 

分 类 号：R961[医药卫生—药理学]