基于基准关联度和模糊层次分析法-熵权法优化银翘马勃散的提取工艺  

Optimization of extraction process for Yinqiao Mabo Powder based on standard relation and fuzzy analytic hierarchy process combined with entropy weight method

作　　者：石羽文 刁元元 姜孟成 刘伟朋 李钠 贾艾玲[1] SHI Yu-wen;DIAO Yuan-yuan;JIANG Meng-cheng;LIU Wei-peng;LI Na;JIA Ai-ling(College of Pharmacy,Changchun University of Chinese Medicine,Changchun 130117,China)

机构地区：[1]长春中医药大学药学院,长春130117

出　　处：《中国新药杂志》2024年第13期1381-1389,共9页Chinese Journal of New Drugs

基　　金：吉林省创新能力建设项目(2021C002);重大疫情防治经典名方制剂储备库建设项目(吉中医药发[2021]11号)。

摘　　要：目的:为保证古今工艺质量一致,采用基准关联度和模糊层次分析法(fuzzy analytic hierarchy process,FAHP)-熵权法综合权重,结合Box-Behnken响应面实验设计优选银翘马勃散的提取工艺。方法:以银翘马勃散中绿原酸、异绿原酸A及异绿原酸C含量的合计量,连翘苷含量加上出膏率和指纹图谱相似度作为评价指标,采用Box-Behnken响应面实验对加水倍数、提取时间及提取次数进行考察,结合基准关联度和FAHP-熵权法计算综合得分,得到最佳提取工艺,并进行工艺验证。结果:优选出银翘马勃散最优提取工艺为:加8倍处方量的水,提取3次,每次1 h。3批工艺验证结果综合评分均值为87.91,RSD值为0.58%。结论:Box-Behnken响应面实验结合基准关联度和FAHP-熵权法优化银翘马勃散的提取工艺合理稳定,具有可行性。Objective:To ensure the equivalence of the ancient and modern processes,a standard relation and the Fuzzy analytic hierarchy process(FAHP)-entropy weight method combined with Box-Behnken response surface test were used to optimize the extraction process of Yinqiao Mabo Powder.Methods:Taking the total amount of chlorogenic acid,isochlorogenic acid A and isochlorogenic acid C,the content of forsythia glycosides,the paste yield and the similarity of fingerprint profile as the evaluation indexes,the Box-Behnken response surface test was used to examine the water addition,extraction time and extraction frequency.Combining the baseline correlation and FAHP-entropy weighting method,a composite score was calculated to obtain the optimal extraction process and the process was validated.Results:The optimal extraction process was selected:adding 8-fold of water and extracting three times for 1 hour each time.The mean score of the three batches of process validation was 87.91 with an RSD of 0.58%.Conclusion:The optimization of the extraction process of Yinqiao Mabo Powder combined with Box-Behnken response surface testing by baseline correlation and FAHP-entropy weight method is reasonable,stable and feasible.

关 键 词：银翘马勃散 Box-Behnken响应面法 基准关联度 模糊层次分析法 熵权法 提取工艺 

分 类 号：R943[医药卫生—药剂学]