精子DNA碎片检测在男性不育症患者临床评估和治疗中的研究进展  

Research progress of sperm DNA fragmentation detection in clinical evaluation and treatment of male infertility

作　　者：张耀东 郭舒筱 颜宏利 Zhang Yaodong;Guo Shuxiao;Yan Hongli(Department of Clinical Laboratory,the 971st Hospital of PLA,Shandong,Qingdao 266071,China;Department of Reproductive Medicine,Changhai Hospital,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军第九七一医院检验科,山东青岛266071 [2]海军军医大学长海医院生殖医学中心,上海200433

出　　处：《发育医学电子杂志》2024年第4期314-320,共7页Journal of Developmental Medicine (Electronic Version)

基　　金：青岛市医药卫生面上项目(2023-WJZD238)。

摘　　要：近年来,我国人口呈现出生率降低和老龄化进程加快的国情,改善和提高男性生育力问题引发社会关注。精子DNA碎片指数(DNA fragmentation index,DFI)作为一种新的精子质量评价标志物,目前广泛应用于临床不育症患者精液样本检测中。随着2023年《精子DNA碎片检测的临床专家共识》发布,为精子DFI应用于不育症患者临床评估和治疗提供了依据和标准。本文将对近年来国内外报道的精子DFI与辅助生殖技术(assisted reproductive technique,ART)治疗结局关系、精子DFI与精子参数一致性关系、精子DFI检测方法评价等研究进行综述。As the decreasing birth rate and accelerating aging process,the research on improving male reproductive ability has taken extensive attention in recently years.As a new marker for sperm quality evaluation,sperm DNA fragmentation index(DFI)has been increasingly used in semen samples detection of male infertility.With the publication of clinical expert consensus on sperm DNA fragmentation detection in 2023,it provides the basis and standard for sperm DFI to clinical evaluation and treatment of male infertility.This review briefly summarizes the research progress on the relationship between sperm DFI and assisted reproductive technique(ART)treatment outcome,the consistency between sperm DFI and sperm parameters,and the evaluation of clinical sperm DFI detection methods in recent years.

关 键 词：精子 DNA碎片 不育症 妊娠 

分 类 号：R698.2[医药卫生—泌尿科学]