道高一尺,魔高一丈:疟疾防控面临的病原学和媒介生物学挑战  

While the priest climbs a post,the devil climbs ten:major biological threats from parasite and vector to malaria control and elimination

作　　者：俞心愉 曹俊[1,2] YU Xinyu;CAO Jun(National Health Commission Key Laboratory of Parasitic Disease Control and Prevention,Jiangsu Provincial Key Laboratory of Parasite and Vector Control Technology,Jiangsu Institute of Parasitic Diseases,Wuxi,Jiangsu 214064,China;Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China)

机构地区：[1]国家卫生健康委员会寄生虫病预防与控制技术重点实验室、江苏省寄生虫与媒介控制技术重点实验室、江苏省血吸虫病防治研究所,江苏无锡214064 [2]南京医科大学公共卫生学院全球健康中心,江苏南京211166

出　　处：《中国血吸虫病防治杂志》2024年第3期228-232,238,共6页Chinese Journal of Schistosomiasis Control

基　　金：江苏省科教能力提升工程(ZDXYS202207)。

摘　　要：疟疾是世界上危害最严重的蚊媒传染病之一。近年来,全球疟疾防控进展迟缓,重要原因之一是来自疟疾病原疟原虫和传播媒介按蚊的生物学挑战。本文针对抗疟药耐药性、疟疾快速诊断试纸条靶标恶性疟原虫富组氨酸蛋白2/3(Plasmodium falciparum histidine-rich protein 2/3,Pfhrp2/3)基因缺失、媒介杀虫剂抗性及按蚊入侵等生物学挑战进行概述,从而为当前疟疾及其媒介相关研究提供参考,亦为疟疾控制和消除策略的制订和调整提供科学依据。Malaria is one of the most serious mosquito-borne infectious diseases in the world.The global malaria control progress has stalled in recent years,which is largely due to the biological threats from the malaria pathogen Plasmodium and the vector Anopheles mosquitoes.This article provides an overview of biological threats to global malaria elimination,including antimalarial drug resistance,deletions in the malaria rapid diagnostic test target P.falciparum histidine-rich protein 2/3(Pfhrp2/3)genes,vector insecticide resistance and emergence of invasive vector species,so as to provide insights into malaria and vector research and the formulation and adjustment of the malaria control and elimination strategy.

关 键 词：疟疾 消除 疟原虫 按蚊 生物学挑战 

分 类 号：R531.3[医药卫生—内科学]