全球消除疟疾的生物学挑战Ⅱ疟疾快速诊断试纸条靶标Pfhrp/3基因缺失  

Biological threats to global malaria eliminationⅡDeletion in the malaria rapid diagnostic test target Plasmodium falciparum histidine-rich protein 2/3 genes

作　　者：徐岁[1] 唐建霞 XU Sui;TANG Jianxia(National Health Commission Key Laboratory of Parasitic Disease Control and Prevention,Jiangsu Provincial Key Laboratory of Parasite and Vector Control Technology,Jiangsu Institute of Parasitic Diseases,Wuxi,Jiangsu 214064,China;Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China)

机构地区：[1]国家卫生健康委员会寄生虫病预防与控制技术重点实验室、江苏省寄生虫与媒介控制技术重点实验室、江苏省血吸虫病防治研究所,江苏无锡214064 [2]南京医科大学公共卫生学院全球健康中心,江苏南京211166

出　　处：《中国血吸虫病防治杂志》2024年第3期239-242,258,共5页Chinese Journal of Schistosomiasis Control

基　　金：国家重点研发计划(2023YFA1801004);江苏省“科教能力提升工程”项目(ZDXYS202207)。

摘　　要：全球疟疾流行依然严峻,疟疾快速诊断试纸条(rapid diagnostic test,RDT)操作简便、检测快速、结果准确,已成为当前疟疾防控中最重要和最广泛使用的诊断工具。但RDT靶标恶性疟原虫富组氨酸蛋白2/3(Plasmodium falciparum histidine-rich protein 2/3,Pfhrp2/3)基因缺失可导致RDT产生假阴性检测结果,被WHO列为全球消除疟疾的四大生物学挑战之一。本文通过回顾RDT在全球疟疾诊断中的应用,分析Pfhrp2/3基因缺失带来的威胁与挑战、提出Pfhrp2/3基因缺失的监测方法、总结RDT检测阴性的原因与对策,为巩固我国消除疟疾成果、助力全球消除疟疾提供参考。The global malaria epidemic is still severe.Because of simple procedures,rapid detection and accuracy results,rapid diagnostic test(RDT)has become the most important and the most widely used diagnostic tool for malaria prevention and control.However,deletions in the RDT target Plasmodium falciparum histidine-rich protein 2/3(Pfhrp2/3)genes may cause falsenegative results of RDT,which has been included as one of the four biological threats to global malaria elimination.This article reviews the applications of RDT in the global malaria diagnosis,analyzes the threats and challenges caused by Pfhrp2/3 gene deletion,proposes methods for monitoring Pfhrp2/3 gene deletion,and summarizes the causes and countermeasures of negative RDT detections,so as to provide insights into consolidation of malaria elimination achievements in China and contributions to global malaria elimination.

关 键 词：疟疾 消除 快速诊断试纸条 富组氨酸蛋白 基因缺失 

分 类 号：R531.3[医药卫生—内科学]