Brønsted酸催化萘酚与丙炔醇的环化反应合成苯并色烯  

Synthesis of Benzochromenes via Brønsted Acid Catalyzed Annulation of Naphthol with Propargyl Alcohols

作　　者：赵聘 尚旭伟 罗清清 梁梦雨 符媛 张明亮 刘澜涛[1,2] Pin Zhao;Xuwei Shang;Qingqing Luo;Mengyu Liang;Yuan Fu;Mingliang Zhang;Lantao Liu(College of Chemistry,Zhengzhou University,Zhengzhou 450001;Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals,School of Chemistry and Chemical Engineering,Shangqiu Normal University,Shangqiu,Henan 476000)

机构地区：[1]郑州大学化学学院,郑州450001 [2]商丘师范学院化学化工学院河南省药物绿色合成工程研究中心,河南商丘476000

出　　处：《有机化学》2024年第6期1920-1928,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21572126,21901152);河南省科技攻关(No.202102310003);河南省商丘市人才支持计划领军人才(No.SQRC202212004)资助项目

摘　　要：苯并色烯广泛存在于天然产物、生物活性分子和有机功能材料中.报道了在温和条件下,以丙炔醇和β-萘酚为原料合成苯并色烯的策略,并以优秀的收率合成了一系列苯并色烯.该方案具有适用范围广、官能团兼容性好、条件温和等优点,且H2O是唯一副产物.此外,该方法操作简便,克级反应可以维持优秀收率,具有实际应用前景.Benzeochromenes, also named as naphthopyrans, are widely found in natural products, bioactive molecules and organic functional materials. A simple and efficient strategy for the synthesis of benzeochromenes with propargyl alcohols and β-naphthols under mild conditions was developed, and a series of benzeochromenes were prepared in excellent yields. This protocol has the advantages of broad scope, functional group diversity and mild conditions with H2O as the only byproduct. Moreover, ease of operation and gram-scale preparation portend the practical application.

关 键 词：萘并吡喃 苯并色烯 丙炔醇 2-萘酚 

分 类 号：O621.251[理学—有机化学]