苯并唑-氮杂环卡宾钯配合物的合成表征及应用  

Syntheses and Structural Characterizations of Benzoxazolyl N-Heterocyclic Carbene-Palladium Complexes and Their Applications

作　　者：孙超 周泉 李传莹[1] 王磊 Chao Sun;Quan Zhou;Chuanying Li;Lei Wang(Department of Chemistry,Zhejiang Sci-Tech University,Hangzhou 310018;Advanced Research Institute&School of Pharmaceutical Sciences,Taizhou University,Taizhou,Zhejiang 318000;Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education,Hangzhou Normal University,Hangzhou 311121;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032)

机构地区：[1]浙江理工大学化学系,杭州310018 [2]台州学院高研院和药学院,浙江台州318000 [3]杭州师范大学有机硅化学及材料技术教育部重点实验室,杭州311121 [4]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海200032

出　　处：《有机化学》2024年第6期1957-1966,共10页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.22071171);浙江省自然科学基金(No.LZ22B020003)资助项目。

摘　　要：合成了6个具有柔性直链烷基或苄基连接体的七元苯并噁唑-氮杂环卡宾钯的新配合物,用NMR,HRMS,FTIR等对其构进行了表征,并用X射线单晶衍射进一步确认了其中3个配合物的结构.晶体解析显示钯配位中心是稍微扭曲的平面四边形构型,其配体中苯并噁唑和氮杂环卡宾平面互成一定角度,不共平面.氮杂环卡宾片段相连的第一个亚甲基上的偕二氢在配合物中表现磁各向异性,亚甲基偕二氢化学位移差(Δδg)随侧链长度增长而变化,侧链为四个碳的直链烷基时,Δδg最大.催化活性应用研究显示,此类配合物对Suzuki-Miyaura反应具有优异的催化活性,并且可应用于两步一锅法合成联苯类偕二氟烯烃化合物.Six seven-membered benzoxazolyl N-heterocyclic carbene(Benzoxa^NHC)palladium complexes with flexible linear alkyl or benzyl linkers were synthesized.Their structures were characterized by NMR,HRMS,and FTIR spectroscopies.The structures of three complexes were further confirmed by X-ray single crystal diffraction.Palladium center adopted slight distorted square planer geometry,and the benzoxazole and NHC planes in its ligand formed a certain angle with each other,not coplanar.The first methylene group connected to a nitrogen-containing heterocyclic carbene fragment exhibited magnetic anisotropy in the complex.The shift difference in the methylene group(Δδg)changed with the increase of the length of the side chain.When the side chain was a linear chain alkyl group of four carbons,Δδg reched maximum.Furthermore,these complexes showed excellent catalytic performance in Suzuki-Miyaura coupling,and could be used to synthesize biphenyl gem-difluoroethenes in the manner of two steps in one pot.

关 键 词：氮杂环卡宾钯 Suzuki-Miyaura偶联 偕二氟烯烃 

分 类 号：O641.4[理学—物理化学] O643.36[理学—化学] O621.251