中性粒细胞与烧伤脓毒症  

Neutrophil and burn sepsis

作　　者：孙炳伟 王逸凡 杨云稀 Sun Bingwei;Wang Yifan;Yang Yunxi(Department of Burn and Plastic Surgery,Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou 215002,China)

机构地区：[1]南京医科大学附属苏州医院烧伤整形科,苏州215002

出　　处：《中华烧伤与创面修复杂志》2024年第7期618-624,共7页Chinese Journal of Burns And Wounds

基　　金：国家自然科学基金联合基金重点项目(U21A20370);国家自然科学基金面上项目(82072217、81772135)。

摘　　要：脓毒症是严重烧伤最常见的并发症,也是危害危重烧伤患者生命的首要因素。烧伤脓毒症患者的病死率高达75%。中性粒细胞是先天性免疫细胞之一,也是感染部位募集最早、最多的免疫细胞,在局部感染的清除和损伤组织修复方面发挥关键作用。众多研究已深入揭示了烧伤脓毒症的发病和进展机制,中性粒细胞在其中的作用逐渐明朗。该文详细阐述了中性粒细胞在烧伤脓毒症发生、发展中的关键机制,并基于中性粒细胞在烧伤脓毒症中的独特生物学行为,探讨了其在烧伤脓毒症预警与预后判断方面的价值以及烧伤脓毒症的潜在治疗手段。Sepsis is the most common complication of severe burns and a primary risk factor for endangering the lives of critically severe burn patients.The mortality rate of burn sepsis patients was up to 75%.Neutrophils are one of the innate immune cells and are the earliest and most recruited immune cells at the site of infection,which play a key role in the removal of local infection and the repair of damaged tissue.Many studies have deeply revealed the pathogenesis and progression mechanism of burn sepsis,in which the role of neutrophils has gradually become clear.This paper elaborated on the key mechanisms of neutrophils in the occurrence and evolution of burn sepsis,explored the value of neutrophils in the early warning and prognosis judgement,and the potential therapeutic methods of burn sepsis based on the unique biological behavior of neutrophils in burn sepsis.

关 键 词：烧伤 脓毒症 中性粒细胞 机制 预警 

分 类 号：R459.7[医药卫生—急诊医学] R644[医药卫生—治疗学]