基于AHP-CRITIC权重分析法结合Box-Behnken设计-响应面法优化盐橘核水提取工艺  

Optimization of Extraction Technique for Salt-Stir-Baking Processed Products of Tangerine Seed by Box-Behnken Response Surface Methodology Based on AHP-CRITIC Weighted Evaluation

作　　者：缪怡烨 周叶[1,2,3,4] 过科家 陈盛君[1,2,3,4] 王仁杰 常运军[1,2,3,4] 王凯玉 刘新宇 Miao Yiye;Zhou Ye;Guo Kejia;Chen Shengjun;Wang Renjie;Chang Yunjun;Wang Kaiyu;Liu Xinyu(Jiangyin Tianjiang Pharmaceutical Co.,Ltd.,Jiangyin 214434,China;Key Technology Laboratory for Preparation and Quality Control of Traditional Chinese Medicine Granules in Jiangsu,Jiangyin 214434,China;Jiangsu Traditional Chinese Medicine Formula Granule Engineering Center,Jiangyin 214434,China;Jiangsu Traditional Chinese Medicine Formula Granule Engineering Research Center,Jiangyin 214434,China)

机构地区：[1]江阴天江药业有限公司,江苏江阴214434 [2]江苏省中药配方颗粒制备与质量控制关键技术重点实验室,江苏江阴214434 [3]江苏省中药配方颗粒工程技术中心,江苏江阴214434 [4]江苏省中药配方颗粒工程研究中心,江苏江阴214434

出　　处：《亚太传统医药》2024年第7期40-45,共6页Asia-Pacific Traditional Medicine

基　　金：江苏省科技成果转化专项资金项目(BA2021018)。

摘　　要：目的:优化盐橘核水提取工艺。方法:以柠檬苦素、诺米林、黄柏酮的转移率及出膏率为评价指标,利用混合加权法(AHP-CRITIC法)确定权重系数,计算多指标综合评分,并结合Box-Behnken设计-响应面法考察饮片粒度、加水量、提取时间的影响,优选盐橘核水提取工艺。结果:优选提取工艺为饮片粒度过6目筛网,一、二煎加水量分别为12倍、10倍,提取时间分别为1.0 h、0.5 h。结论:优选出的提取工艺稳定可行,可为盐橘核工业化生产提供参考。Objective:To optimize of the extraction process of salt-stir-baking processed products of Tangerine seed.Methods:The transfer rate of limonin,nomilin and fluteone and paste yield were used as indicators,the weight coefficient was determined by mixed weighting method(AHP-CRITIC method),the comprehensive score of multiple indicators was calculated,and the effects of tablet particle size,extraction time and water addition were investigated by Box-Behnken design-response surface method,and the extraction process of salt-stir-baking processed products of Tangerine seed was optimized.Results:The optimal extraction process was that the particle size of the pieces was over 6 mesh screen,and the amount of water added for the first and second extractions were 12 times and 10 times,and the extraction time was 1.0h and 0.5h,respectively.Conclusion:The optimal extraction process was stable and feasible,which can provide a reference for the industrial production of salt orange core.

关 键 词：盐橘核 AHP法 CRTICT法 Box-Behnken设计-响应面法 提取工艺 

分 类 号：R284[医药卫生—中药学]