经典名方开心散制剂工艺研究  

Study on the Pharmaceutical Technology of Classic Famous Prescription Kaixin Powder

作　　者：姜璐 孙婉婷 李天媛 谭茹锦 杨淼 王钰洁 王海波[1] Jiang Lu;Sun Wanting;Li Tianyuan;Tan Rujin;Yang Miao;Wang Yujie;Wang Haibo(College of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian 116600,China)

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600

出　　处：《亚太传统医药》2024年第4期54-57,共4页Asia-Pacific Traditional Medicine

基　　金：辽宁省科技厅自然科学基金项目(20180550681);沈阳市科技局重点实验室项目(skf20174703);辽宁中医药大学创新创业项目(X202110162046)。

摘　　要：目的:研究经典名方开心散提取制剂工艺,提高活性成分转移率,保证药品质量。方法:采用水蒸气蒸馏法提取石菖蒲挥发油,Box-Behnken实验设计方法优化所得挥发油包合工艺;以总多糖量、总皂苷量和出膏率为指标,通过均匀设计法确定后续水煎煮提取的料液比、时间和次数等条件。结果:确定β-环糊精与挥发油比例为6∶1,包合温度40℃,包合时间为80 min的包合工艺;水煎煮提取条件为料液比1∶12,提取时间3 h,提取次数3次。结论:该实验确定了开心散提取制剂工艺条件,挥发油成分转移率增加近94.94%。Objective:The extraction technology of Classic Famous Prescription Kaixin Powder was studied to improve the transfer rates of components and ensure the quality of Kaixin Powder proprietary medicine.Methods:The volatile oil was extracted by steam distillation and the inclusion process of volatile oil was optimized by the Box-Behnken experimental design method.With total polysaccharide content,total saponin content,and extract rate as indexes,the solid-liquid ratio,extraction time,and frequency of water decocting extraction were optimized by a uniform design method.Results:The process of volatile oil inclusion was determined to be β-cyclodextrin to volatile oil ratio of 6∶1,inclusion temperature of 40 ℃,and inclusion time of 80 mins.The extraction conditions were solid-liquid ratio 1∶12,extraction time 3 h,and three times.Conclusion:The pharmaceutical conditions of volatile oil inclusion and extraction of Kaixin Powder proprietary medicine were determined,and the transfer rate of volatile oil in the extracts was increased by nearly 94.94% obtained by the optimizing process conditions.

关 键 词：开心散 成分转移率 响应面设计法 均匀设计法 

分 类 号：R284.1[医药卫生—中药学] R917.101[医药卫生—中医学]