不同给药途径治疗关节镜术后肝肾亏虚型膝骨关节炎疗效研究  

Study on the Effect of Different Drug Administration Routes in the Treatment of Knee Osteoarthritis with Liver and Kidney Deficiency after Arthroscop

作　　者：葛梦涛 陈大伟[1,2,3,4] 陈建锋 李浩[1,2,3,4] 雷杰[1,2,3,4] 叶锡光 熊昌源[1,2,3,4] Ge Mengtao;Chen Dawei;Chen Jianfeng;Li Hao;Lei Jie;Ye Xiguang;Xiong Changyuan(Hubei University of Chinese Medicine,Wuhan 430060,China;The Hospital Affiliated to Hubei University of Chinese Medicine,Wuhan 430060,China;Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430060,China;Hubei Provincial Institute of Traditional Chinese Medicine,Wuhan 430060,China)

机构地区：[1]湖北中医药大学,湖北武汉430060 [2]湖北中医药大学附属医院,湖北武汉430060 [3]湖北省中医院,湖北武汉430060 [4]湖北省中医药研究院,湖北武汉430060

出　　处：《亚太传统医药》2024年第4期93-97,共5页Asia-Pacific Traditional Medicine

基　　金：国家中医药管理局“熊昌源名老中医药专家传承工作室”建设项目(国中医药人教函[2022]75号)。

摘　　要：目的:探讨关节镜术后内服及局部外用药物两种方式治疗肝肾亏虚型膝骨关节炎的临床疗效。方法:回顾性研究2017年3月-2019年2月,于湖北省中医院骨伤科住院的经关节镜有限清理术,按滑膜病理形态进行局部滑膜辨证分型为肝肾亏虚型的骨关节炎患者,其中20例内服中药患者为对照组,20例局部外用中药患者为对照组。比较两组术前、术后7天、14天、28天及3个月的VAS评分、Lysholm评分、Womac评分,比较组间评分,并统计两组临床疗效。结果:对照组和观察组在早期均能减轻疼痛,促进膝关节功能恢复,有较好疗效,但观察组疗效更为持久,并避免了对患者胃肠功能的扰乱和其他疾病药物的影响。观察组与对照组术后28天及3个月VAS评分、Womac评分比较差异有统计学意义。两组患者术前与术后各项评分比较差异均有统计学意义。结论:局部外用中药治疗关节镜术后肝肾亏虚型骨关节炎临床疗效较内服中药好,且避免了中药内服的一些弊端,值得进一步推广。Objective:To investigate the clinical effect of internal administration and local external drug in the treatment of knee osteoarthritis with liver and kidney deficiency after arthroscopy.Methods:A retrospective study of patients with liver and kidney deficiency type which they were diagnosed according to the diagnostic criteria and dialectically classified according to the pathology of the synovial membrane by limited arthroscopy in the Department of Orthopedics and Traumatology of Hubei Provincial Hospital of Traditional Chinese Medicine from March 2017 to February 2019.Among them,20 patients with internal Chinese medicine were the control group,and 20 patients with local external Chinese medicine were the control group.Both groups of patients underwent limited arthroscopic debridement first,while the treatment group started to take Chinese medicine locally and the control group took Chinese medicine internally three days after surgery.The VAS scores,Lysholm scores,and Womac scores of the two groups before the operation,7 days,14 days,28 days,and 3 months after the operation were compared,while the scores between the groups were compared and the clinical efficacy of the two groups was calculated.Results:Both the control group and the observation group can relieve pain in the early stage and promote the recovery of knee joint function which both have a good effect.However,the observation group has a longer-lasting effect and avoids the disturbance of the patient's gastrointestinal function and the influence of drugs on other diseases.There was a statistically significant difference in VAS score and Womac score between the observation group and the control group at 28 days and 3 months postoperatively,while both of each group were statistically significant differences in the scores between the two groups before and after the operation.Conclusion:The clinical efficacy of taking Chinese medicine locally and externally in the treatment of liver and kidney deficiency osteoarthritis after arthroscopic surgery is better

关 键 词：膝关节 骨关节炎 关节镜 给药途径 

分 类 号：R274[医药卫生—中医骨伤科学]