中国中老年人群高尿酸血症危险因素Meta分析  

Risk factors of hyperuricemia in middle-aged and elderly people in China:a meta-analysis

作　　者：陈曾丽 蒋运兰[2] 谢红梅 彭寒梅 刘露 李洁 CHEN Zengli;JIANG Yunlan;XIE Hongmei;PENG Hanmei;LIU Lu;LI Jie(School of Nursing,Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China;the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine)

机构地区：[1]成都中医药大学护理学院,四川成都610072 [2]成都中医药大学附属医院

出　　处：《包头医学院学报》2024年第7期76-81,共6页Journal of Baotou Medical College

基　　金：国家科技部重点专项(2020YFC2003104)。

摘　　要：目的:系统评价中国中老年人群高尿酸血症(hyperuricemia,HUA)危险因素。方法:计算机检索Embase、Web of Science、Pubmed、The Cochrane Library、中国知网(CNKI)、万方数据库(Wangfang data)、中国生物医学文献数据库(CBM)、维普数据库(VIP)等数据库,收集有关中国中老年人群HUA危险因素的文献,检索时限为建库至2022年3月。采用RevMan 5.3软件和Stata 14.0软件进行Meta分析。结果:共纳入20篇文献,包括72020例HUA患者,Meta分析结果显示,高血压(OR=1.43,95%CI:1.26~1.62),年龄≥45岁(OR=1.11,95%CI:1.07~1.15),饮酒(OR=1.47,95%CI:1.31~1.65),高体质指数(body mass index,BMI)(OR=1.06,95%CI:1.02~1.19),高甘油三酯(triglyceride,TG)(OR=1.81,95%CI:1.58~2.07),肾功能不全(OR=2.88,95%CI:1.76~4.73),高胆固醇(total cholesterol,TC)(OR=1.21,95%CI:1.09~1.33),高血肌酐(OR=1.69,95%CI:1.53~1.85),中心性肥胖(OR=1.52,95%CI:1.30~1.79)和高尿素氮(OR=1.53,95%CI:1.23~1.90)是中国中老年人群HUA危险因素(P<0.05);高密度脂蛋白(high density lipoprotein,HDL-C)(OR=0.50,95%CI:0.36~0.70)和高血糖(OR=0.75,95%CI:0.66~0.86)是中国中老年人群HUA保护因素(P<0.05)。结论:高血压、年龄≥45岁、饮酒、高BMI、高TG、肾功能不全、高TC、高血肌酐、中心性肥胖、高尿素氮是中国中老年人群HUA危险因素,高血糖和HDL-C是中国中老年人群HUA保护因素。Objective:To systematically evaluate the risk factors of hyperuricemia(HUA)in middle-aged and elderly people in China.Methods:The Embase,Web of Science,PubMed,the Cochrane Library,Chinese National Knowledge Infrastructure(CNKI),Wangfang Data,Chinese Biomedical Literature Database(CBM),and VIP database were selected to collect literaturse on risk factors of HUA in middle-aged and elderly people in China.The retrieval time limitation was defined from the establishment of the database until March 2022.RevMan 5.3 and Stata 14.0 software were used for data analysis.Results:A total of 20 studies were included,including 72020 cases of HUA patient.Meta-analysis results showed that hypertension(OR=1.43,95%CI:1.26-1.62),age≥45(OR=1.11,95%CI:1.07-1.15),alcohol consumption(OR=1.47,95%CI:1.31-1.65),high body mass index(BMI)(OR=1.06,95%CI:1.02-1.19),high triglyceride(TG)(OR=1.81,95%CI:1.58-2.07),renal insufficiency(OR=2.88,95%CI:1.76~4.73),high cholesterol(TC)(OR=1.21,95%CI:1.09~1.33),high serum creatinine(OR=1.69,95%CI:1.53~1.85),central obesity(OR=1.52,95%CI:1.30-1.79)and high urea nitrogen(OR=1.53,95%CI:1.23-1.90)were risk factors for HUA in middle-aged and elderly people in China.High density lipoprotein(HDL-C)(OR=0.50,95%CI:0.36~0.70)and hyperglycemia(OR=0.75,95%CI:0.66-0.86)were protective factors to HUA in middle-aged and elderly people in China.Conclusion:Hypertension,age≥45 years,alcohol consumption,high BMI,high TG,renal insufficiency,high TC,high serum creatinine,central obesity and high urea nitrogen are the risk factors for HUA in middle-aged and elderly people in China.Meanwhile,high blood glucose and HDL-C are the protective factors to HUA.

关 键 词：高尿酸血症 HUA危险因素 中老年 META分析 

分 类 号：R589.7[医药卫生—内分泌]