宏基因二代测序协助沙门菌致复发性腹膜透析相关性腹膜炎诊治1例及文献复习  

Diagnosis and treatment of recurrent peritonitis associated with peritoneal dialysis caused by Salmonella identified through metagenomic next-generation sequencing:a case report and literature review

作　　者：张喆[1] 刘笑芬[1] 谢超[1] 孔耀中[1] 叶佩仪[1] Zhang Zhe;Liu Xiaofen;Xie Chao;Kong Yaozhong;Ye Peiyi(Department of Nephrology,the First People's Hospital of Foshan,Foshan 528000,China)

机构地区：[1]佛山市第一人民医院肾内科,佛山528000

出　　处：《中华肾脏病杂志》2024年第6期487-490,共4页Chinese Journal of Nephrology

摘　　要：本文报道1例应用宏基因二代测序诊治沙门菌致复发性腹膜透析相关性腹膜炎的病例。该患者因“慢性肾脏病5期”规律行腹膜透析治疗。1个月前因“腹膜透析相关性腹膜炎”入院,透出液细菌培养结果为沙门菌。经抗感染治疗3周出院,但出院第12天再次因腹膜炎入院,此次治疗前透出液宏基因二代测序和细菌培养结果均为沙门菌,经腹腔联合静脉抗感染3周,并于出院前再次行宏基因二代测序评估病原体治愈后出院。This paper reports a case of recurrent peritoneal dialysis-associated peritonitis caused by Salmonella,as identified through metagenomic next-generation sequencing.This patient was treated regularly with peritoneal dialysis due to stage 5 chronic kidney disease.One month ago,she was hospitalized for peritoneal dialysis-associated peritonitis.The result of bacterial culture of the dialysate was Salmonella,and she was discharged after anti-infective treatment for 3 weeks.However,on the 12th day after discharge,the patient was readmitted to the hospital due to peritonitis.Both metagenomic next-generation sequencing and bacterial culture of the fluid confirmed the presence of Salmonella.After 3 weeks of intraperitoneal and intravenous anti-infection treatment,the patient underwent metagenomic next-generation sequencing to assess pathogen eradication before discharge.

关 键 词：沙门菌属 腹膜透析 腹膜炎 宏基因组 二代测序 

分 类 号：R692.5[医药卫生—泌尿科学] R656.41[医药卫生—外科学]