雌激素及其受体在病理性疼痛中的作用机制  

Mechanism of Estrogen and Estrogen Receptors in Pathologic Pain

作　　者：何帮靖 周明旺[2] 张朋威 HE Bangjing;ZHOU Mingwang;ZHANG Pengwei(Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Orthopaedics,Gansu Hospital of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃省兰州市730000 [2]甘肃省中医院矫形骨科,甘肃省兰州市730000

出　　处：《中国全科医学》2024年第33期4204-4209,共6页Chinese General Practice

基　　金：国家自然科学基金资助项目(81860861,82060876);中医药高级人才工作室建设项目。

摘　　要：病理性疼痛是一种严重的慢性疾病,包括炎症性疼痛、神经病理性疼痛和癌性疼痛。大量研究证实,雌激素及其受体与病理性疼痛之间密切相关,对其发生和发展有着不可忽视的作用。结合近几年国内外相关文献,本文阐述了雌激素及其受体在病理性疼痛中作用机制的相关研究进展,旨在为病理性疼痛的防治和治疗提供理论依据并指导未来研究方向。Pathologic pain is a serious chronic disease,including inflammatory pain,neuropathic pain and cancer pain.Previous studies have proved a close correlation of estrogen and its receptors with pathologic pain,which plays an important role in its occurrence and development,therefore,it has attracted the attention of many researchers at home and abroad.Combining the relevant literature at home and abroad in recent years,this paper reviews the relevant research progress of the mechanism of estrogen and its receptors in pathologic pain,in order to provide a theoretical basis for the prevention and treatment of pathologic pain,as well as the guidance for future research.

关 键 词：雌激素 雌激素受体 炎症性疼痛 神经病理性疼痛 癌性疼痛 

分 类 号：R441.1[医药卫生—诊断学]