基于下丘脑-垂体-性腺轴探析补肾法治疗2型糖尿病生精障碍的思路  

The Idea of Kidney Tonifying Therapy for Spermatogenesis Disorder in Type 2 Diabetes Mellitus Based on the Hypothalamic-pituitary-gonadal Axis

作　　者：卢威 杨云松 林连美 刘琼 赵敏 李佳 梁凤霞 吴松 LU Wei;YANG Yunsong;LIN Lianmei;LIU Qiong;ZHAO Min;LI Jia;LIANG Fengxia;WU Song(Clinical College of Chinese Medicine,Hubei University of Chinese Medicine,Wuhan 430061,China;Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion,Wuhan 430061,China;School of Basic Medicine,Hubei University of Chinese Medicine,Wuhan 430065,China;College of Acupuncture and Orthopedics,Hubei University of Traditional Chinese Medicine,Wuhan 430061,China)

机构地区：[1]湖北中医药大学中医临床学院,湖北省武汉市430061 [2]针灸治未病湖北省协同创新中心,湖北省武汉市430061 [3]湖北中医药大学基础医学院,湖北省武汉市430065 [4]湖北中医药大学针灸骨伤学院,湖北省武汉市430061

出　　处：《中国全科医学》2024年第33期4210-4214,共5页Chinese General Practice

基　　金：湖北省中医药管理局2023-2024年度中医药青年人才项目(ZY2023Q042);湖北省教育厅科学中青年人才项目(Q20222005);2022年国家中药管理局青年岐黄学者项目(国中医药人教函[2022]256号);全国名老中医药专家(王华教授)传承工作室建设项目(国中医药人教函[2022]75号)。

摘　　要：糖尿病(DM)高血糖病理状态是导致男性生精障碍的重要因素之一,下丘脑-垂体-性腺(HPG)轴是人体全身植物性功能、神经内分泌网络的重要枢纽,生理上主导人类生殖及生长发育,病理上又可受到DM高血糖病理状态的影响,是2型糖尿病(T2DM)生精障碍发生、发展过程中的关键机制之一,肾虚是生精障碍和T2DM共同的病因病机。肾藏精所体现的“主生殖、生髓充脑”功能与HPG轴功能相似,补肾法对HPG轴功能具有调节改善作用,为补肾法治疗T2DM生精障碍奠定理论基础。补肾经典方剂在治疗DM与生精障碍上相得益彰,为临床以补肾法防治T2DM生精障碍之不育症提供了思路和方法。Diabetic hyperglycemia in males is a significant contributing factor to the development of spermatogenesis disorder.The hypothalamic-pituitary-gonadal(HPG) axis serves as a crucial center for autonomic sexual function and the neuroendocrine network within the human body.It dominates physiological prominence in human reproduction,growth,and development,while also being susceptible to hyperglycemia,which is one of the key mechanisms in the development of spermatogenic disorder in type 2 diabetes mellitus(T2DM).This mechanism involves kidney deficiency,which is a common etiology and pathogenesis of both spermatogenesis disorder and T2DM.The kidney storing essence,which encompasses the functions of "dominating reproduction,manufacturing marrow to fill up the brain" bears similarities to the HPG axis.Kidney tonifying therapy can regulate and improve the function of HPG axis,thereby establishing a theoretical basis for the use of kidney tonification therapy in the treatment of spermatogenesis disorder in T2DM.The traditional formula of tonifying the kidney can serve as a complementary treatment for both DM and spermatogenesis disorder.This approach offers a conceptual framework and methodology for the prevention and treatment of T2DM-induced infertility through kidney tonification.

关 键 词：下丘脑-垂体系统 糖尿病 2型 生精障碍 补肾 理论探讨 

分 类 号：R322.54[医药卫生—人体解剖和组织胚胎学]