穿心莲分子生药学研究进展  

Research progress in molecular pharmacognosy of Andrographis paniculata

作　　者：张龙[1,2,3] 李静宇 徐世强 王继华 ZHANG Long;LI Jing-yu;XU Shi-qiang;WANG Ji-hua(Key Laboratory of Crop Genetic Improvement of Guangdong Province,Crops Research Institute,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China;Guangdong Provincial Engineering and Technology Research Center for Conservation and Utilization of the Genuine Southern Medicinal Resources,Guangzhou 510640,China;College of Plant Science and Technology,Huazhong Agricultural University,Wuhan 430070,China)

机构地区：[1]广东省农业科学院作物研究所、广东省农作物遗传改良重点实验室,广东广州510640 [2]广东省道地南药资源保护与利用工程中心,广东广州510640 [3]华中农业大学植物科学技术学院,湖北武汉430070

出　　处：《中国中药杂志》2024年第13期3432-3440,共9页China Journal of Chinese Materia Medica

基　　金：广东省自然科学基金项目(2023A1515010426);广东省科技计划项目(2023B1212060038);广东省农业科学院创新基金项目(202305)。

摘　　要：分子生药学是一门新兴的交叉学科,以分子生物学和中药学为基础,旨在研究药用植物的次生代谢产物合成和分子调控功能。穿心莲Andrographis paniculata是一种传统大宗中药材,具有保肝利胆、清热解毒和抗菌消炎等重要功效。穿心莲生产过程中受品种、产地环境、种植技术等原因造成的品质不稳定是穿心莲产业持续发展的重要限制因素,基于分子生药学的研究手段,采用现代组学技术进行穿心莲次生代谢产物调控研究已成为解决其品质问题的关键方法。该文总结了近年来穿心莲分子生药学领域的研究成果,包括资源的分子鉴定、遗传多样性、多组学技术、有效成分生物合成和种质创新等,并对该领域的发展趋势进行了展望。深入推动穿心莲分子生药学研究将为进一步开发其药用价值提供更加科学和有效的技术支持,为穿心莲新品种培育提供新思路,有效推动穿心莲产业的高质量可持续发展。Molecular pharmacognosy as an emerging interdisciplinary subject based on molecular biology and Chinese materia medica aims to study the synthesis and molecular regulation of secondary metabolites in medicinal plants.Andrographis Herba,the dried aboveground part of Andrographis paniculata,has liver-protecting,bile secretion-promoting,heat-clearing,toxin-removing,antimicrobial,and anti-inflammatory effects.The quality instability caused by plant varieties,environment,and technology in the production of A.paniculata is a limiting factor for the sustainable development of this industry.Based on the research methods of molecular pharmacognosy and omics,the regulation of secondary metabolites of A.paniculata has become the key solution to the quality problems of A.paniculata.This paper summarized the recent research achievements in the molecular pharmacognosy of A.paniculata,including molecular identification of the resources,genetic diversity,multi-omics,biosynthesis of active compounds,and germplasm resource innovation,and prospected the future development trend in this field.In-depth research of molecular pharmacognosy of A.paniculata will provide more scientific and effective technical support for the development of its medicinal value,give new insights into the cultivation of new A.paniculata varieties,and promote the high-quality sustainable development of this industry.

关 键 词：穿心莲 分子生药学 品质 有效成分 种质创新 

分 类 号：S567.219[农业科学—中草药栽培]