60821例围生儿出生缺陷与产妇年龄构成关系及转归情况分析  

Analysis of the relationship and outcomes between birth defects and maternal age composition in 60821 perinatal infants

作　　者：韦洁 冯宝莹 彭振仁 梁丽芳 陈碧艳 黄秀宁[1,2,3] 何升 WEI Jie;FENG Baoying;PENG Zhenren;LIANG Lifang;CHEN Biyan;HUANG Xiuning;HE Sheng(Guangxi Key Laboratory of Birth Defects Research and Prevention,Nanning,Guangxi 530000,China;Birth Defects Prevention and Control Institute of Guangxi Zhuang Autonomous Region,Nanning,Guangxi 530000,China;Maternity and Child Health Care of Guangxi Zhuang Autonomous Region,Nanning,Guangxi 530000,China)

机构地区：[1]广西出生缺陷防治基础研究重点实验室,广西南宁530000 [2]广西出生缺陷预防控制研究所,广西南宁530000 [3]广西壮族自治区妇幼保健院,广西南宁530000

出　　处：《中国优生与遗传杂志》2024年第5期1078-1082,共5页Chinese Journal of Birth Health & Heredity

基　　金：广西医学高层次骨干人才“139”计划(G202003023);广西壮族自治区卫生健康委员会重点(培育)实验室建设(ZJC202011);广西重点实验室运行补助项目计划(21-220-22);基于地理信息系统的广西出生缺陷空间数据库建立及空间建模分析(Z20210056)。

摘　　要：目的分析2017—2023年广西围生儿出生缺陷与产妇年龄构成关系及转归情况,为制定出生缺陷预防干预措施提供依据。方法收集2017—2023年广西出生缺陷医院监测资料,将产妇按年龄划分为低龄、适龄和高龄3个组,统计各产妇年龄组构成比,出生缺陷发生率,对不同年龄组的出生缺陷疾病顺位与出生缺陷转归进行差异分析。结果2017—2023年广西高龄产妇构成比呈上升趋势,2023年高龄产妇构成比达22.67%;高龄产妇构成比较高的前3个市为柳州市、南宁市和桂林市;低龄、适龄和高龄组出生缺陷发生率分别为133.01/万、141.07/万、182.02/万;高龄组先天性心脏病和唐氏综合征的发生率高于适龄和低龄组;低龄组多指(趾)和总唇裂的发生率高于适龄和高龄组;低龄组围生儿出生缺陷存活率最低,死胎死产率、0~6 d死亡率最高。结论2017—2023年广西高龄产妇构成比呈逐年上升趋势,出生缺陷防控形势严峻;应继续推进出生缺陷三级预防措施,降低严重出生缺陷及不良妊娠结局的发生率,提高出生人口素质。Objective Analyzing the relationship and outcomes between birth defects and maternal age composition among perinatal infants in Guangxi from 2017 to 2023.And to provide a foundation for the development of interventions to prevent birth defects.Methods The monitoring data of birth defects in Guangxi Birth Defects Hospital from 2017 to 2023 was collected.Pregnant women were divided into three age groups:the young group,the appropriate age group,and the elderly group.The composition ratio and the incidence of birth defects were recorded for each maternal age group.The analysis was done to determine the difference between the order of birth defects and the outcomes of birth defects in different age groups.Results The percentage of elderly pregnant women in Guangxi increased from 2017 to 2023,reaching 22.67%in 2023.Liuzhou,Nanning,and Guilin were the three cities with the highest percentage of elderly pregnant women.The incidence of birth defects in the young group,middle-aged group and elderly group was 133.01/10000,141.07/10000,and 182.02/10000,respectively.The incidence of congenital heart defects and Down's syndrome was higher in the elderly group than in the appropriate age and young groups.Polydactyly and cleft lip were more prevalent in the young group than in the appropriate age and elderly groups.Young pregnant women had the lowest survival rate for perinatal infants with birth defects,with the highest rates of stillbirth and mortality within 6 days.Conclusion The percentage of elderly pregnant women in Guangxi has increased every year from 2017 to 2023,and the priority is still to prevent and control birth defects.Promoting three-level preventive measures for birth defects is crucial to reduce the incidence of serious birth defects and adverse pregnancy outcomes.This method has the potential to enhance the quality of the birth population.

关 键 词：广西 围生儿 出生缺陷 产妇年龄 转归 

分 类 号：R714[医药卫生—妇产科学]