炎症与血液高凝状态在反复妊娠丢失中的作用  

The role of inflammation and hypercoagulability in recurrent pregnant loss

作　　者：徐梦浩 朱文馨 郑翠红 XU Menghao;ZHU Wenxin;ZHENG Cuihong(Institute of Integrated Traditional Chinese and Western Medicine,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院中西医结合研究所,湖北武汉430030

出　　处：《中国优生与遗传杂志》2024年第5期1089-1094,共6页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金(81874388)。

摘　　要：反复妊娠丢失指与同一配偶连续发生2次及以上在妊娠28周之前的妊娠丢失,包括生化妊娠,约1%~5%的夫妇受此疾病困扰。反复妊娠丢失的病因和发病机制复杂多样,目前已知炎症和血液高凝状态是其重要因素。本文回顾了这一领域的现有知识,以3种子宫局部免疫细胞,即子宫自然杀伤细胞、巨噬细胞、T细胞为代表讨论了炎症在反复妊娠丢失中的作用,以及血液高凝状态在反复妊娠丢失中的作用,并讨论了二者的交互作用。本文旨在为未来对反复妊娠丢失的机制研究、诊断和治疗提供思路。Recurrent pregnant loss(RPL)is defined as 2 or more consecutive pregnancy losses with the same partner occurring before 28 weeks of gestation,including biochemical pregnancy,about 1%-5%of couples are afflicted with this disease.The etiology and pathogenesis of RPL are complex,with inflammation and hypercoagulability known as important factors.This paper reviewed the current knowledge in this field,discussed the role of inflammation in RPL,represented by three local immune cells—uterine natural killer cells,macrophages,and T cells,discussed the role of hypercoagulability in RPL,and discussed the interaction between inflammation and hypercoagulability.This review aimed to provide thoughts for research on mechanisms,diagnosis and treatment of RPL in the future.

关 键 词：反复妊娠丢失 炎症 血液高凝状态 

分 类 号：R714.21[医药卫生—妇产科学]