黏结蛋白聚糖-1在慢性子宫内膜炎诊断中的研究进展  

Research progress on syndecan 1 in the diagnosis on chronic endometritis

作　　者：黄博文 蔡华蕾 程惠 陈卓 HUANG Bowen;CAI Hualei;CHENG Hui;CHEN Zhuo(Department of Reproductive Medicine,The Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou 550004,China;Department of Gynecology,The Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou 550004,China)

机构地区：[1]贵州医科大学附属医院生殖医学中心,贵州贵阳550004 [2]贵州医科大学附属医院妇科,贵州贵阳550004

出　　处：《中国优生与遗传杂志》2024年第5期1095-1100,共6页Chinese Journal of Birth Health & Heredity

基　　金：2023年贵州省基础研究计划(自然科学类)项目(黔科合基础-ZK[2023]一般352)。

摘　　要：慢性子宫内膜炎(CE)是一种临床症状隐匿、影响育龄妇女生殖健康的持续性局部非特异性炎症疾病,其特点是子宫内膜间质内浆细胞的浸润。黏结蛋白聚糖-1是一种蛋白聚糖,特异性地表达于浆细胞膜的细胞膜上,常被应用在CE组织病理学检查的诊断方法中。由于CE尚无公认的诊断标准,关于CE病理诊断浆细胞的最小诊断数量亦存在争议。本文通过阐述慢性子宫内膜炎与不孕症的关系、黏结蛋白聚糖-1的病理生理学特点、黏结蛋白聚糖-1对女性生殖健康的影响及黏结蛋白聚糖-1作为CE诊断标志物的研究进展,旨在为探讨统一且准确的慢性子宫内膜炎诊断标准提供思路。Chronic endometritis(CE)is a clinically covert,persistent local non-specific inflammatory disease impacting the reproductive health of women of childbearing age.It is characterized by plasma cell infiltration in the endometrial stroma.Syndecan 1,a proteoglycan,is specifically expressed on the cell membrane of plasma cells and is frequently utilized in the diagnostic methods of CE histopathology.Due to the absence of universally accepted diagnostic standards for CE,there is controversy regarding the minimum number of plasma cells required for CE pathological diagnosis.This article examines the relationship between chronic endometritis and infertility,the pathophysiological characteristics of syndecan 1,its impact on women's reproductive health,and its research progress as a diagnostic marker for CE.The goal is to offer insights for developing a unified and accurate diagnostic standard for chronic endometritis.

关 键 词：慢性子宫内膜炎 黏结蛋白聚糖-1 CD138 不孕症 

分 类 号：R711.32[医药卫生—妇产科学]