多裂黄檀中两个新的异黄酮类化合物  

Two new isoflavones from Dalbergia rimosa Roxb.

作　　者：王维玉 陈文娇 黄美芳 卢澄生[2,3,4] 冯旭[1,2,3] 梁臣艳 韦建华 WANG Wei-yu;CHEN Wen-jiao;HUANG Mei-fang;LU Cheng-sheng;FENG Xu;LIANG Chen-yan;WEI Jian-hua(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China;Teaching Center of Experiment and Practical Training,Guangxi University of Chinese Medicine,Nanning 530200,China;National Demonstration Center for Experimental Chinese Medicine Education,Guangxi University of Chinese Medicine,Nanning 530200,China;Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,China)

机构地区：[1]广西中医药大学药学院,广西南宁530200 [2]广西中医药大学教学实验实训中心,广西南宁530200 [3]广西中医药大学中药学国家级实验教学示范中心,广西南宁530200 [4]广西中医药大学附属瑞康医院,广西南宁530011

出　　处：《药学学报》2024年第7期2053-2057,共5页Acta Pharmaceutica Sinica

基　　金：广西自然科学基金资助项目(2023JJA140637);国家重点研究计划项目(2019YFC17123012);广西科技基地和人才专项(桂科AD20238058);广西中医药管理局科研课题(GXZYA20220122);广西一流学科建设开放课题自然科学项目(2019XK129);广西壮瑶药重点实验室开放课题(GXZY22.2019-10)。

摘　　要：研究多裂黄檀Dalbergia rimosa Roxb.根茎的化学成分。采用硅胶、MCI和Sephadex LH-20柱色谱以及半制备高效液相色谱等技术进行分离纯化,通过波谱数据鉴定化合物结构。从多裂黄檀根茎的乙酸乙酯部位中分离得到13个化合物,分别鉴定为多裂异黄酮A、B(1和2)、刺芒柄花素(3)、7,4′-二甲氧基异黄酮(4)、4′,6,7-trimethoxyisoflavone(5)、鹰嘴豆芽素A(6)、樱黄素(7)、7-O-methyltectorigenin(8)、3′-hydroxydaidzein(9)、orobol7,3′-dimethyl ether(10)、2′,7-dihydroxy-4′,5′-dimethoxyisoflavone(11)、pruinosanone E(12)、caviunin(13)。其中,化合物1和2为新化合物,化合物3~13为首次从该植物中分离得到。化合物9和11对DPPH自由基有显著清除作用。Studies on chemical constituents in the rhizome of Dalbergia rimosa Roxb.The chemical constituents from the ethyl acetate part of D.rimosa were isolated and purified by silica gel,MCI gel,Sephadex LH-20 gel and semi-preparative HPLC,and the stuctures were identified by spectral method.Thirteen compounds were isolated from the ethyl acetate part of the rhizome of D.rimosa and identified as dalbergiaisoflavones A,B(1,2),formononetin(3),7,4′-dimethoxyisoflavone(4),4′,6,7-trimethoxyisoflavone(5),biochanin A(6),prunetin(7),7-O-methyltectorigenin(8),3′-hydroxydaidzein(9),orobol 7,3′-dimethyl ether(10),2′,7-dihydroxy-4′,5′-dimethoxyisoflavone(11),pruinosanone E(12),caviunin(13).Compounds 1 and 2 are new compounds,and compounds 3-13 were isolated from this plant for the first time.Compounds 9 and 11 had remarkable scavenging effect on DPPH free radicals.

关 键 词：多裂黄檀 异黄酮 多裂异黄酮A 多裂异黄酮B 抗氧化 

分 类 号：R284[医药卫生—中药学]