杜仲中的一个新环烯醚萜类化合物  

A new iridoid from Eucommia ulmoides

作　　者：周诗琪 郝志友[1,2] 杨梦 肖超远[1,2] 张俊阳 张博文 陶思琦 郑晓珂 冯卫生 ZHOU Shi-qi;HAO Zhi-you;YANG Meng;XIAO Chao-yuan;ZHANG Jun-yang;ZHANG Bo-wen;TAO Si-qi;ZHENG Xiao-ke;FENG Wei-sheng(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province,Zhengzhou 450046,China;Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]河南省中药开发工程技术研究中心,河南郑州450046 [3]呼吸疾病中医药防治省部共建协同创新中心,河南郑州450046

出　　处：《药学学报》2024年第7期2062-2068,共7页Acta Pharmaceutica Sinica

基　　金：中央引导地方科技发展专项资金([2016]149);河南省高层次人才特殊支持计划(ZYQR201810080)。

摘　　要：利用硅胶、Sephadex LH-20和Toyopearl HW-40C等柱色谱及半制备液相等分离纯化方法,从杜仲中分离得到11个化合物。运用现代波谱学方法确定化合物的结构,分别鉴定为neoeucommiate A(1)、(7S,8R)-dihydrodehydrodiconiferyl alcohol(2)、urolignoside(3)、ficusal(4)、tiruneesiin(5)、glochidioboside(6)、forsythialansides B(7)、ecdysanolB(8)、(+)-syringaresinol-4-O-β-D-glucopyranoside(9)、(+)-pinoresinol-4-O-[6??-O-vanilloyl]-β-Dglucopyranoside(10)和samsesquinoside(11)。其中化合物1为新化合物,化合物3~7、10、11为首次从杜仲中分离得到。Eleven compounds were isolated from Eucommia ulmoides by silica gel,Sephadex LH-20,HW-40C column chromatography and semi-preparative HPLC.Their structures were identified by modern spectroscopic methods as neoeucommiate A(1),(7S,8R)-dihydrodehydrodiconiferyl alcohol(2),urolignoside(3),ficusal(4),tiruneesiin(5),glochidioboside(6),forsythialansides B(7),ecdysanol B(8),(+)-syringaresinol-4-O-β-D-glucopyranoside(9),(+)-pinoresinol 4-O-[6ʹʹ-O-vanilloyl]-β-D-glucopyranoside(10),samsesquinoside(11).Compound 1 is a new compound,compounds 3−7,10 and 11 were isolated from Eucommia ulmoides for the first time.

关 键 词：杜仲 neoeucommiate A 环烯醚萜 木脂素 化学成分 

分 类 号：R284[医药卫生—中药学]