新作用机制的抗肿瘤药物进展  

Advances in anti-tumor drugs with new mechanisms of action

作　　者：张百红 岳红云 Zhang Baihong;Yue Hongyun(Department of Oncology,940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Lanzhou 730050,China;Department of Ophthalmology,940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Lanzhou 730050,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院肿瘤科,兰州730050 [2]中国人民解放军联勤保障部队第九四〇医院眼科,兰州730050

出　　处：《国际肿瘤学杂志》2024年第6期354-358,共5页Journal of International Oncology

基　　金：甘肃省自然科学基金(22JR5RA007);联勤保障部队第九四〇医院课题(2021yxky052)。

摘　　要：细胞毒性药物、分子靶向药物和免疫检查点抑制剂构成了目前肿瘤系统治疗的基本模式, 新作用机制的抗肿瘤药物, 包括激酶抑制剂、治疗性抗体、核酸阻断剂、治疗性疫苗、基因编辑免疫细胞、微型机器人和数字药物将改变现有的治疗模式。靶向神经、多糖、脂质和菌群的药物可能逐步进入肿瘤临床。Cytotoxic agents,molecular targeted agents and immune checkpoint inhibitors consist of the fundamental model of cancer systematic treatments.Anti-tumor drugs with new mechanisms of action,including kinase inhibitors,therapeutic antibodies,nucleic acid blocks,therapeutic vaccines,gene-edited immune cells,living microrobots and digital drugs,will change this existing model.Drugs targrting nerves,polysaccharides,lipids and microflora may gradually enter clinical applications.

关 键 词：肿瘤 抗肿瘤药 治疗 

分 类 号：R979.1[医药卫生—药品]