一种查尔酮衍生物的合成及晶体结构  

Synthesis and crystal structure of a chalcone derivative

作　　者：高艳蓉 高洁[1] 问娟娟 朱周静 唐文强 GAO Yan-rong;GAO Jie;WEN Juan-juan;ZHU Zhou-jing;TANG Wen-qiang(School of Pharmacy,Shaanxi Institute of International Trade&Commerce,Xianyang 712046,China;Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province,Xianyang 712046,China)

机构地区：[1]陕西国际商贸学院医药学院,陕西咸阳712046 [2]陕西省中药绿色制造技术协同创新中心,陕西咸阳712046

出　　处：《精细与专用化学品》2024年第7期42-44,共3页Fine and Specialty Chemicals

基　　金：咸阳市分子影像与药物合成重点实验室项目(2021QXNL-PT-0008);陕西省教育厅一般专项项目(23JK0328)。

摘　　要：在乙醇溶液中,4-氨基苯乙酮(化合物2)与4-甲基苯甲醛(化合物3)发生Aldol缩合反应得到可衍生化的查尔酮衍生物——(E)-1-(4-氨基苯基)-3-(对甲苯基)丙-2-烯-1-酮(化合物1)。对该Aldol缩合反应进行优化,结果发现:当物料比n(化合物3)∶n(化合物2)=2.2∶1,40℃下反应4h,化合物1的收率可达到58.8%(以化合物2为基准计算)。采用XRD单晶衍射对产物的晶体结构进行了表征。The synthesis and crystal structure of a derivable chalcone derivative,(E)-1-(4-aminophenyl)-3-(p-tolyl)prop-2-en-1-one(compound 1) were reported.The target molecule(compound 1) was obtained by Aldol condensation of 4-aminoacetophenone(compound 2) with 4-methylbenzaldehyde(compound 3) in ethanol solution.The Aldol condensation reaction was optimized.It was found that the yield was 58.8%(calculated based on 4-aminoacetophenone) when the mole ratio of n(compound 3)∶n(compound 2)=2.2∶1 and the reaction was carried out at 40℃ for 4 hours.The crystal structure of the product was characterized by XRD single crystal diffraction.

关 键 词：查尔酮衍生物 ALDOL缩合反应 合成 单晶结构 

分 类 号：TQ463[化学工程—制药化工]