基于金纳米笼基底的抗菌纳米药物研究进展  

The advancement of research on antibacterial nanodrugswith Au nanocages as a substrate

作　　者：张国凌 王倩倩 潘越哲 俞国君 龚培燕 许丰瑞 ZHANG Guo-ling;WANG Qian-qian;PAN Yue-zhe;YU Guo-jun;GONG Pei-yan;XU Feng-rui(Shaanxi Provincial Key Laboratory of Phytochemistry,AIE Research Center,College of Chemistry and Chemical Engineering,Baoji University of Arts and Sciences,Baoji 721013,Shaanxi,China)

机构地区：[1]宝鸡文理学院化学化工学院,AIE(聚集诱导发光)研究中心,陕西省植物化学重点实验室,陕西宝鸡721013

出　　处：《宝鸡文理学院学报（自然科学版）》2024年第2期50-56,共7页Journal of Baoji University of Arts and Sciences(Natural Science Edition)

基　　金：陕西省教育厅专项科学研究计划项目(23JK0282);陕西省科技厅自然科学基础研究计划青年项目(2024JC-YBQN-0107);陕西省科技厅创新能力支撑计划-科技创新团队(2022TD-36);国家自然科学基金面上项目(52173152)。

摘　　要：目的 简要概述金纳米笼(Au nanocages, AuNCs)材料的制备及与其他药物联合抗菌的疗效,为进一步抗菌研究发展提供参考。方法 通过查找文献,分类归纳近年来以AuNCs为基底的抗菌纳米药物的制备及应用。结果 简要概述了AuNCs的制备方法及在新型抗菌纳米材料中AuNCs基底发挥的作用,综述了2016-2023年发现的以AuNCs为基底的抗菌纳米药物。讨论了AuNCs在生物医学领域的应用,并展望了AuNCs复合材料的未来发展方向和应用。结论 研究以AuNCs为基底的抗菌纳米药物及其所对应的抗菌策略,对进一步开发灵敏高效的新型抗菌纳米材料具有重要意义。Purposes—To review briefly the preparation of Au nanocages(AuNCs)and the antibacterial effect of AuNCs in combination with other drugs so as to provide a reference for further antibacterial research and development.Methods—The preparation and application of antibacterial nanomaterials based on Au nanocages in recent years were summarized through literature search and classification.Results—The preparation method of AuNCs and the role of AuNCs substrate in new antibacterial nanomaterials are briefly reviewed and the AuNCs-based antibacterial nanomaterials are reviewed which were discovered from 2016 to 2023.The application of AuNCs in the field of biomedicine is discussed,and the future development direction and application of AuNCs are prospected.Conclusions—The study of AuNCs-based antimicrobial nanomaterials and their corresponding antimicrobial strategies is of great significance for the further development of novel antimicrobial nanomaterials.

关 键 词：金纳米笼 介孔结构 光热转化 抗菌作用 细菌生物被膜 

分 类 号：O611.4[理学—无机化学]