ICU病人多重耐药菌感染危险因素的Meta分析  

Risk factors of multidrug-resistant bacteria infection in ICU patients:a Meta-analysis

作　　者：姚雨菲 孙海超 胡艺 YAO Yufei;SUN Haichao;HU Yi(School of Nursing·School of Public Health,Yangzhou University,Jiangsu 225000 China)

机构地区：[1]扬州大学护理学院·公共卫生学院,江苏225000 [2]扬州大学附属医院

出　　处：《循证护理》2024年第15期2673-2680,共8页Chinese Evidence-Based Nursing

摘　　要：目的:系统评价重症监护室(ICU)病人发生多重耐药菌(MDRO)感染的危险因素。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、EMbase、the Cochrane Library、Web of Science、CIHANL公开发表的ICU病人MDRO感染危险因素的研究。提取纳入文献的资料,采用纽卡斯尔-渥太华量表(NOS)进行质量评价,采用RevMan 5.4.1软件进行Meta分析。结果:共纳入30篇文献,涉及18 302例病人。Meta分析结果显示,急性生理与慢性健康评分、抗生素治疗、糖尿病、慢性肺部疾病、机械通气、ICU住院时间、留置导尿时间、中心静脉置管等均为ICU病人MDRO感染的危险因素(P<0.05)。结论:现有证据表明,ICU病人感染MDRO的危险因素较多,应根据病人的不同情况,采取有针对性的预防和控制措施,减少MDRO感染的发生。Objective:To systematically evaluate the risk factors for the development of multidrug-resistant organism(MDRO)infections in ICU patients.Methods:Computer searched of publicly available studies on risk factors for MDRO infection in ICU patients on CNKI,WanFang Database,VIP,CBM,PubMed,EMbase,the Cochrane Library,Web of Science,and CIHANL.The data of the included literature were extracted,the Newcastle-Ottawa Scale(NOS)was used to evaluate the quality of the included literature,and RevMan 5.4.1 was used for Meta-analysis.Results:A total of 30 articles with 18302 patients were included.Meta-analysis results showed that APACHEⅡscore,antibiotic therapy,diabetes mellitus,chronic lung disease,mechanical ventilation,duration of ICU stay,duration of indwelling catheterization,and central venous placement were risk factors for MDRO infection in ICU patients(P<0.05).Conclusion:Current evidence shows that there are many risk factors for MDRO infection in ICU patients,and targeted preventive and control measures should be taken to reduce the occurrence of MDRO infection according to the different conditions of patients.

关 键 词：重症监护室 多重耐药菌 感染 危险因素 META分析 

分 类 号：R473[医药卫生—护理学]