阿奇霉素序贯治疗与红霉素静脉滴注治疗小儿呼吸道支原体感染的效果比较  

Comparison of the effects of sequential treatment with azithromycin and intravenous infusion of erythromycin in the treatment of pediatric respiratory mycoplasma infection

作　　者：冯瑾 Feng Jin(Liuxin People's Hospital in Quanshan District,Xuzhou City,Jiangsu Province 221000)

机构地区：[1]徐州市泉山区柳新人民医院,江苏徐州221000

出　　处：《医学前沿》2024年第3期112-115,共4页Frontiers of Medicine

摘　　要：目的:为了有效提高小儿呼吸道支原体感染的治疗效果,深入探究对患儿采取阿奇霉素序贯治疗与红霉素静脉滴注治疗的效果。方法:从指尖(末梢血)采集诊断为肺炎支原体感染患儿中选取60例参与实验研究,时间为2023年1月~2023年12月,分为两组,对照组采取注射用阿奇霉素,观察组采取阿奇霉素序贯以及红霉素静脉滴注治疗,比较两组患儿治疗效果的差异。结果:观察结果显示,相较于对照组,观察组患者的咳嗽症状平均在6.02天±2.03天内消失,肺部湿啰音在7.13天±0.82天内消散,发热症状则在2.03天±0.52天内得到控制,这些数据均显著短于对照组的8.14天±1.29天、8.92天±1.05天和3.68天±1.14天;治疗前,两组患者血清中的炎症因子水平无显著统计学差异(P>0.05)。然而,治疗后,观察组的炎症标志物水平显著降低,具体为TNF-α降至12.18±3.07、IL-6降至16.58±3.91、hs-CRP降至5.19±1.83,而对照组对应数值分别为16.24±3.62、20.39±5.14、21.65±6.18,显示出观察组在控制炎症反应方面更为有效。在安全性方面,观察组仅报告1例恶心呕吐案例,而对照组出现6例,治疗效果总结显示,观察组的有效率达到了28/30,明显高于对照组的23/30。结论:对肺炎支原体感染的患儿采用阿奇霉素序贯治疗与红霉素静脉滴注治疗能够有效的改善患儿咳嗽,发热等症状,降低炎症因子,减少不良反应发生情况,提高治疗效果。In order to effectively improve the treatment effect of respiratory mycoplasma infection in children,this study aims to explore the effects of sequential treatment with azithromycin and intravenous infusion of erythromycin on children.Method:Sixty children diagnosed with Mycoplasma pneumoniae infection were selected from fingertip(peripheral blood)to participate in the experimental study,from January 2023 to December 2023.They were divided into two groups:the control group received injection of azithromycin,while the observation group received sequential treatment with azithromycin and intravenous infusion of erythromycin.The differences in treatment effects between the two groups of children were compared.Result:The observation results showed that compared to the control group,the cough symptoms of the observation group patients disappeared on average within 6.02±2.03 days,lung moist rales dissipated within 7.13±0.82 days,and fever symptoms were controlled within 2.03±0.52 days.These data were significantly shorter than the control group's 8.14±1.29 days,8.92±1.05 days,and 3.68±1.14 days;Before treatment,there was no significant statistical difference in the levels of inflammatory factors in the serum of the two groups of patient(s P>0.05).However,after treatment,the levels of inflammatory markers in the observation group significantly decreased,specifically TNF-αdecreased to 12.18±3.07,IL-6 decreased to 16.58±3.91,and hs CRP decreased to 5.19±1.83,while the corresponding values in the control group were 16.24±3.62,20.39±5.14,and 21.65±6.18,respectively,indicating that the observation group was more effective in controlling inflammatory reactions.In terms of safety,the observation group only reported one case of nausea and vomiting,while the control group reported six cases.The summary of treatment effects showed that the effective rate of the observation group reached 28/30,significantly higher than the 23/30 of the control group.Conclusion:Sequential treatment with azithromycin and intravenous inf

关 键 词：呼吸道支原体感染 红霉素静脉滴注 阿奇霉素序贯 

分 类 号：R72[医药卫生—儿科]