巨噬细胞加帽蛋白在肿瘤侵袭和转移中的作用研究进展  

Research progress in roles of macrophage-capping protein in tumor invasion and metastasis

作　　者：崔霞 肖智勇 刘峰 周文霞 CUI Xia;XIAO Zhiyong;LIU Feng;ZHOU Wenxia(National Key Laboratory of National Security Specially Needed Medicines,Academy of Military Medical Sciences,Beijing 100850,China;Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]军事医学研究院国家安全特需药品全国重点实验室,北京100850 [2]南京中医药大学,江苏南京210023

出　　处：《中国药理学与毒理学杂志》2024年第7期542-549,共8页Chinese Journal of Pharmacology and Toxicology

基　　金：天津市科技计划项目(22ZYJDSS00080)。

摘　　要：巨噬细胞加帽蛋白(CapG)作为凝溶胶蛋白超家族成员之一,是机体内普遍存在的多功能肌动蛋白结合蛋白,在乳腺癌、膀胱癌及前列腺癌等多种肿瘤中高表达,可促进肿瘤细胞的转移与侵袭。本文主要对CapG的结构、功能、及其在肿瘤侵袭和转移中的作用和相关信号通路进行综述。Macrophage-capping protein(CapG)is a member of the gelsolin superfamily.It is a universal multifunctional actin binding protein in the body and highly expressed in breast cancer,bladder cancer,prostate cancer and other types of cancer,which can promote the metastasis and invasion of cancer cells.This article reviews the structure,function,related signal pathways and roles of CapG in tumor invasiveness.

关 键 词：巨噬细胞加帽蛋白 结构 功能 信号通路 肿瘤侵袭 

分 类 号：R966[医药卫生—药理学] R73[医药卫生—药学]