医用聚氨酯合成所用有机催化剂及其生物毒性研究进展  

Research Progress in Organocatalysts Used in the Synthesis of Medical Polyurethanes and Their Biotoxicity

作　　者：赵代国 张明杰 李震[2] 兰婉玲 蒙明姜 谭鸿[2] ZHAO Daiguo;ZHANG Mingjie;LI Zhen;LAN Wanling;MENG Mingjiang;TAN Hong(Sichuan Provincial Institute for Drug Control(Sichuan Medical Device Testing Center),Chengdu 611731,China;College of Polymer Science and Engineering,Sichuan University,Chengdu 610065,China;Chongqing Medical Device Quality Inspection Center,Chongqing 400015,China)

机构地区：[1]四川省药品检验研究院(四川省医疗器械检测中心),成都611731 [2]四川大学高分子科学与工程学院,成都610065 [3]重庆医疗器械质量检验中心,重庆400015

出　　处：《四川大学学报（医学版）》2024年第4期807-812,共6页Journal of Sichuan University(Medical Sciences)

基　　金：国家重点研发计划项目(No.2020YFC1107000);四川省科技计划重点研发项目(No.2023YFS0017)资助。

摘　　要：医用聚氨酯以其良好的生物相容性和优良的物理机械性能成为应用最广泛的生物医用材料之一。催化剂是医用聚氨酯合成过程必不可少的一种添加剂,其可以提高合成效率和材料性能。然而,催化剂可能会影响聚氨酯的生物相容性,对人体健康产生潜在危害。本文总结了近年来医用聚氨酯材料合成中所使用的常见有机催化剂及其生物毒性相关研究的进展。首先,将回顾医用聚氨酯材料合成中常用催化剂类型及其特点;随后,将重点关注这些催化剂可能存在的生物毒性;最后,对未来医用聚氨酯材料合成中催化剂选择提出建议。通过深入了解合成医用聚氨酯材料中催化剂的性质和生物毒性,分析当前存在的问题与面临的挑战,这将有助于更好地指导医用聚氨酯材料设计和探讨未来的发展方向,从而提高医用聚氨酯材料的生物相容性和安全性,推动其在临床应用中的进一步发展与应用。Medical polyurethanes have emerged as a leading choice for biomedical applications owing to their exceptional biocompatibility and good physical and mechanical properties.Catalysts play a crucial role as additives in the synthesis of medical polyurethanes,enhancing synthesis efficiency and material properties.However,the catalysts used may affect the biocompatibility of polyurethanes and pose potential harm to human health.This review encapsulates the latest findings regarding the catalysts employed in the synthesis of medical polyurethane materials and their biotoxicity.Initially,we reviewed the prevalent types of catalysts used in the synthesis of medical polyurethane materials and described their distinctive characteristics.Subsequently,our focus shifted to exploring the potential biotoxicity associated with these catalysts.Finally,we provided a forward-looking perspective and recommendations for the future trajectory of catalyst selection in the synthesis of medical polyurethane materials.By acquiring a more profound understanding of the properties and biotoxicity of catalysts used in the synthesis of medical polyurethane materials,and by uncovering existing issues and challenges,we can better guide the design of medical polyurethane materials.This,in turn,enables us to chart the course for future development and ultimately enhance the biocompatibility and safety profiles of medical polyurethane materials.Such advancements will promote the continued development and application of medical polyurethane materials in clinical settings.

关 键 词：聚氨酯 催化剂 有机锡 有机铋 生物毒性 研究进展 

分 类 号：R318.08[医药卫生—生物医学工程]