Nanomaterial-assisted wearable glucose biosensors for noninvasive real-time monitoring:Pioneering point-of-care and beyond  

作　　者：Moein Safarkhani Abdullah Aldhaher Golnaz Heidari Ehsan Nazarzadeh Zare Majid Ebrahimi Warkiani Omid Akhavan YunSuk Huh Navid Rabiee 

机构地区：[1]NanoBio High-Tech Materials Research Center,Department of Biological Sciences and Bioengineering,Inha University,Incheon,22212,Republic of Korea [2]Department of Chemistry,Sharif University of Technology,Tehran,Iran [3]School of Natural Sciences,Massey University,Private Bag 11222,Palmerston North,4410,New Zealand [4]School of Chemistry,Damghan University,Damghan,36716-45667,Iran [5]School of Biomedical Engineering,University of Technology Sydney,Sydney,NSW,2007,Australia [6]Department of Physics,Sharif University of Technology,P.O.Box 11155-9161,Tehran,Iran [7]Centre for Molecular Medicine and Innovative Therapeutics,Murdoch University,Perth,WA 6150,Australia [8]School of Engineering,Macquarie University,Sydney,New South Wales,2109,Australia

出　　处：《Nano Materials Science》2024年第3期263-283,共21页纳米材料科学（英文版）

基　　金：supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT) (No.2022M3J7A1062940,2021R1A5A6002853,and 2021R1A2C3011585);supported by the Technology Innovation Program (20015577)funded by the Ministry of Trade,Industry&Energy (MOTIE,Korea)。

摘　　要：This review explores glucose monitoring and management strategies,emphasizing the need for reliable and userfriendly wearable sensors that are the next generation of sensors for continuous glucose detection.In addition,examines key strategies for designing glucose sensors that are multi-functional,reliable,and cost-effective in a variety of contexts.The unique features of effective diabetes management technology are highlighted,with a focus on using nano/biosensor devices that can quickly and accurately detect glucose levels in the blood,improving patient treatment and control of potential diabetes-related infections.The potential of next-generation wearable and touch-sensitive nano biomedical sensor engineering designs for providing full control in assessing implantable,continuous glucose monitoring is also explored.The challenges of standardizing drug or insulin delivery doses,low-cost,real-time detection of increased blood sugar levels in diabetics,and early digital health awareness controls for the adverse effects of injectable medication are identified as unmet needs.Also,the market for biosensors is expected to expand significantly due to the rising need for portable diagnostic equipment and an ever-increasing diabetic population.The paper concludes by emphasizing the need for further research and development of glucose biosensors to meet the stringent requirements for sensitivity and specificity imposed by clinical diagnostics while being cost-effective,stable,and durable.

关 键 词：Glucose sensor BIOSENSOR Wearable devices NONINVASIVE Real-time monitoring 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TP212.3[自动化与计算机技术—检测技术与自动化装置]