甲硝唑凝胶与甲硝唑泡腾片治疗细菌性阴道病及对阴道微生态恢复的影响  

Effect of Metronidazole Gel and Metronidazole Effervescent Tablets on Bacterial Vaginosis and Vaginal Microecological Recovery

作　　者：欧阳丽华 OUYANG Li-hua(Department of Obstetrics and Gynecology,the First Maternal and Child Health Hospital of Anyuan County,Anyuan 342100,Jiangxi,China)

机构地区：[1]安远县第一妇幼保健院妇产科,江西安远342100

出　　处：《医学信息》2024年第15期67-70,共4页Journal of Medical Information

摘　　要：目的比较甲硝唑凝胶与甲硝唑泡腾片治疗细菌性阴道病及对阴道微生态恢复的影响。方法选取2022年6月-2023年5月安远县第一妇幼保健院收治的细菌性阴道病患者60例作为研究对象,按照随机数字表法将所有患者分为对照组和研究组,每组30例。对照组应用甲硝唑泡腾片治疗,研究组应用甲硝唑凝胶治疗。比较两组临床疗效、症状改善时间(白带异常消失时间、阴道瘙痒消失时间、实验室检查结果转阴时间)、阴道微生态恢复情况(阴道菌群密集度分布情况和pH值)、炎性因子水平[白细胞介素-2(IL-2)、白细胞介素-8(IL-8)及白细胞介素-13(IL-13)]。结果研究组总有效率高于对照组(P<0.05);研究组白带异常消失时间、阴道瘙痒消失时间、实验室检查结果转阴时间均短于对照组(P<0.05);两组治疗后pH>4.5者均降低,且研究组降低更多(P<0.05);两组阴道菌群密集度1~2级者均增加,且研究组增加更多(P<0.05);研究组IL-2、IL-8、IL-13水平低于对照组(P<0.05)。结论甲硝唑凝胶治疗细菌性阴道病的效果优于甲硝唑泡腾片,可改善患者的阴道微生态环境,减轻机体炎症反应,缩短症状改善时间,值得应用。Objective To compare the effects of metronidazole gel and metronidazole effervescent tablets in the treatment of bacterial vaginosis and the recovery of vaginal microecology.Methods A total of 60 patients with bacterial vaginosis admitted to the First Maternal and Child Health Hospital of Anyuan County from June 2022 to May 2023 were selected as the research objects.All patients were divided into control group and study group according to the random number table method,with 30 patients in each group.The control group was treated with metronidazole effervescent tablets,and the study group was treated with metronidazole gel.The clinical efficacy,symptom improvement time(leucorrhea disappearance time,vaginal itching disappearance time,laboratory test results negative time),vaginal microecological recovery(vaginal flora density distribution and pH value),inflammatory factor levels[interleukin-2(IL-2),interleukin-8(IL-8)and interleukin-13(IL-13)]were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group(P<0.05).The disappearance time of leucorrhea abnormality,disappearance time of vaginal itching and negative conversion time of laboratory examination results in the study group were shorter than those in the control group(P<0.05).After treatment,the patients with pH>4.5 in both groups decreased,and the study group decreased more(P<0.05).The vaginal flora density of grade 1-2 in the two groups increased,and the study group increased more(P<0.05).The levels of IL-2,IL-8 and IL-13 in the study group were lower than those in the control group(P<0.05).Conclusion The effect of metronidazole gel in the treatment of bacterial vaginosis is better than that of metronidazole effervescent tablets.It can improve the vaginal microecological environment of patients,reduce the body's inflammatory response,and shorten the time of symptom improvement.It is worthy of application.

关 键 词：甲硝唑凝胶 甲硝唑泡腾片 细菌性阴道病 阴道微生态 

分 类 号：R711.3[医药卫生—妇产科学]