清热利湿方联合甲硝唑阴道凝胶治疗细菌性阴道炎的临床疗效及对阴道局部微环境的影响  

Clinical Effect of Qingre Lishi Decoction Combined with Metronidazole Vaginal Gel in the Treatment of Bacterial Vaginosis and its Effect on Vaginal Local Microenvironment

作　　者：张桂梅 ZHANG Gui-mei(Outpatient Obstetrics and Gynecology,Yugan County People's Hospital,Yugan 335100,Jiangxi,China)

机构地区：[1]余干县人民医院妇产科,江西余干335100

出　　处：《医学信息》2024年第15期83-86,共4页Journal of Medical Information

摘　　要：目的分析清热利湿方联合甲硝唑阴道凝胶治疗细菌性阴道炎的临床疗效及对阴道局部微环境的影响。方法选取2020年1月-2023年4月我院诊治的60例细菌性阴道炎患者为研究对象,采用随机数字表法分为对照组(n=30)和观察组(n=30),对照组采用甲硝唑阴道凝胶治疗,观察组在对照组基础上联合清热利湿方治疗,比较两组临床疗效、临床症状改善时间、阴道局部微环境(pH值、阴道菌群密集度评分)、阴道分泌物Nugent评分、复发率、不良反应发生率。结果观察组治疗总有效率为96.67%,高于对照组的83.33%(P<0.05);观察组阴道瘙痒、白带异常、外阴疼痛、黏膜充血改善时间均短于对照组(P<0.05);两组治疗后阴道pH值、阴道菌群密集度均低于治疗前,且观察组低于对照组(P<0.05);两组治疗后阴道分泌物Nugent评分均低于治疗前,且观察组低于对照组(P<0.05);随访1个月,观察组复发率为6.67%,低于对照组的16.67%(P<0.05);观察组不良反应发生率为10.00%,与对照组的6.67%比较,差异无统计学意义(P>0.05)。结论清热利湿方联合甲硝唑阴道凝胶治疗细菌性阴道炎的效果良好,可有效改善临床症状及阴道局部微环境,降低阴道分泌物Nugent评分及复发率,且不增加临床不良反应。Objective To analyze the clinical efficacy of Qingre Lishi decoction combined with metronidazole vaginal gel in the treatment of bacterial vaginitis and its effect on vaginal local microenvironment.Methods Sixty patients with bacterial vaginitis diagnosed and treated in our hospital from January 2020 to April 2023 were selected as the research objects.They were divided into control group(n=30)and observation group(n=30)by random number table method.The control group was treated with metronidazole vaginal gel,and the observation group was treated with Qingre Lishi decoction on the basis of the control group.The clinical efficacy,improvement time of clinical symptoms,vaginal local microenvironment(pH value,vaginal flora intensity score),vaginal secretion Nugent score,recurrence rate and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.67%,which was higher than 83.33%in the control group(P<0.05).The improvement time of vaginal itching,abnormal leucorrhea,vulvar pain and mucosal congestion in the observation group was shorter than that in the control group(P<0.05).After treatment,the vaginal pH value and vaginal flora density in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).The Nugent scores of vaginal secretions in the two groups after treatment were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).After 1 month of follow-up,the recurrence rate of the observation group was 6.67%,which was lower than 16.67%of the control group(P<0.05).The incidence of adverse reactions in the observation group was 10.00%,compared with 6.67%in the control group,the difference was not statistically significant(P>0.05).Conclusion Qingre Lishi decoction combined with Metronidazole Vaginal Gel has a good effect in the treatment of bacterial vaginitis,which can effectively improve t

关 键 词：清热利湿方 甲硝唑阴道凝胶 细菌性阴道炎 阴道局部微环境 

分 类 号：R711.31[医药卫生—妇产科学]