女性泌尿生殖道感染情况调查及支原体药敏分析  

Investigation of Female Genitourinary Tract Infection and Drug Sensitivity Analysis of Mycoplasma

作　　者：李秋平 邱世香 赖华英 何六六 LI Qiu-ping;QIU Shi-xiang;LAI Hua-ying;HE Liu-liu(Laboratory Department of Shicheng County Maternal and Child Health Hospital,Shicheng 342700,Jiangxi,China;The Second Affiliated Hospital of Gannan Medical College,Ganzhou 341600,Jiangxi,China)

机构地区：[1]石城县妇幼保健院检验科,江西石城342700 [2]赣南医学院第二附属医院,江西赣州341600

出　　处：《医学信息》2024年第15期119-122,126,共5页Journal of Medical Information

基　　金：赣州市科技计划项目(编号:2023DXNS4801)。

摘　　要：目的研究女性泌尿生殖道感染中的支原体感染情况及药敏试验结果。方法以2023年1月-12月石城县妇幼保健院收治的694例泌尿生殖道感染女性为研究对象,开展支原体分离与药敏试验,统计其支原体感染情况,比较不同年龄段女性的支原体检出情况,同时分析支原体对不同抗菌药物的敏感性。结果694例泌尿生殖道感染女性中,支原体感染者共406例,支原体感染率为58.50%,其中解脲脲原体(Uu)阳性占比为47.26%(328/694)、人型支原体(Mh)阳性占比为1.15%(8/694)、Uu+Mh混合阳性占比为10.09%(70/694)。不同年龄段支原体检出率比较,差异有统计学意义(P<0.05),其中支原体检出率由高到低依次为31~40岁、21~30岁、20岁以下、41~50岁、50岁以上。药敏试验显示,敏感性排名前3位药物为强力霉素、美满霉素、交沙霉素,其在Uu、Mh及Uu+Mh感染中的药物敏感性均超过85%;敏感性排名后3位为克林霉素、莫西沙星与加替沙星,其在Uu、Mh及Uu+Mh感染中的药物敏感性均低于20%,而克拉霉素与阿奇霉素仅在Uu单一感染中具有较高敏感性。结论支原体感染为女性泌尿生殖道感染主要类型,以Uu感染最为常见,多见于31~40岁及21~30岁年龄段患者,其敏感抗菌药物包括强力霉素、美满霉素、交沙霉素等。Objective To study the mycoplasma infection and drug sensitivity test results in female genitourinary tract infection.Methods A total of 694 women with genitourinary tract infection admitted to Shicheng County Maternal and Child Health Hospital from January to December 2023 were selected as the research objects.Mycoplasma isolation and drug sensitivity test were carried out,and the mycoplasma infection was counted.The detection of mycoplasma in women of different ages was compared,and the sensitivity of mycoplasma to different antibiotics was analyzed.Results Among the 694 women with genitourinary tract infection,there were 406 cases of mycoplasma infection,and the infection rate of mycoplasma was 58.50%.Among them,the positive rate of ureaplasmaurealyticum(Uu)was 47.26%(328/694),the positive rate of mycoplasma hominis(Mh)was 1.15%(8/694),and the mixed positive rate of Uu+Mh was 10.09%(70/694).There were significant differences in the detection rate of mycoplasma among different age groups(P<0.05),and the detection rate of mycoplasma from high to low was 31-40 years old,21-30 years old,41-50 years old,<20 years old,>50 years old.Drug sensitivity test showed that the top three drugs in sensitivity were doxycycline,minocycline and josamycin,and their drug sensitivity in Uu,Mh and Uu+Mh infection was more than 85%.Clindamycin,moxifloxacin and gatifloxacin ranked the last three in sensitivity,and their drug sensitivity in Uu,Mh and Uu+Mh infection was lower than 20%,while clarithromycin and azithromycin had high sensitivity only in Uu single infection.Conclusion Mycoplasma infection is the main type of female genitourinary tract infection,and Uu infection is the most common.It is more common in patients aged 31-40 years old and 21-30 years old.Its sensitive antibiotics include doxycycline,minocycline and josamycin.

关 键 词：泌尿生殖道感染 支原体阳性 药敏分析 解脲脲原体 人型支原体 四环素类抗生素 

分 类 号：R374[医药卫生—病原生物学]