二羟丙茶碱治疗慢性阻塞性肺疾病的临床疗效及不良反应观察  

Observation of Clinical Efficacy and Adverse Reactions of Diprophylline in the Treatment of Chronic Obstructive Pulmonary Disease

作　　者：肖穷 XIAO Qiong(Department of Respiratory Medicine,Hukou County People's Hospital,Hukou 332500,Jiangxi,China)

机构地区：[1]湖口县人民医院呼吸内科,江西湖口332500

出　　处：《医学信息》2024年第15期130-133,共4页Journal of Medical Information

摘　　要：目的研究二羟丙茶碱治疗慢性阻塞性肺疾病(COPD)的临床疗效及不良反应。方法选取2023年1月-6月湖口县人民医院收治的60例COPD患者,经随机数字表法分为对照组(30例)与观察组(30例)。对照组行常规对症治疗,观察组在其基础上加用二羟丙茶碱治疗,比较两组临床疗效、症状缓解时间(喘息、咳嗽、咳痰)、病情改善情况[COPD患者自我评估测(CAT)、圣·乔治医院呼吸问题调查问卷(SGRQ)评分]、不良反应。结果观察组治疗有效率高于对照组(P<0.05);观察组症状(喘息、咳嗽、咳痰)缓解时间短于对照组(P<0.05);两组治疗后CAT、SGRQ评分低于治疗前,且观察组CAT、SGRQ评分低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论二羟丙茶碱在COPD患者中具有确切治疗作用,可提高其临床疗效,加速症状缓解,促进病情转归,且具有良好用药安全性。Objective To study the clinical efficacy and adverse reactions of diprophylline in the treatment of chronic obstructive pulmonary disease(COPD).Methods Sixty patients with COPD admitted to Hukou County People's Hospital from January to June 2023 were selected and divided into control group(30 patients)and observation group(30 patients)by random number table method.The control group was treated with routine symptomatic treatment,and the observation group was treated with diprophylline on the basis of the control group.The clinical efficacy,symptom relief time(wheezing,cough,sputum),improvement of the disease[COPD assessment test(CAT),St.George's Hospital Respiratory Questionnaire(SGRQ)score]and adverse reactions were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The remission time(wheezing,cough,sputum)in the observation group was shorter than that in the control group(P<0.05).The scores of CAT and SGRQ in the two groups after treatment were lower than those before treatment,and the scores of CAT and SGRQ in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Diprophylline has a definite therapeutic effect in patients with COPD,which can improve its clinical efficacy,accelerate symptom relief,promote disease outcome,and has good drug safety.

关 键 词：慢性阻塞性肺疾病 二羟丙茶碱 症状缓解 不良反应 

分 类 号：R563.9[医药卫生—呼吸系统]