Duphaston as a suitable medication for women taking intracytoplasmic sperm injection to treat infertility  

作　　者：Leila Naserpour Katayon Berjis Sanaz Soleymani Moud Rahil Jannatifar 

机构地区：[1]Department of Reproductive Biology,Academic Center for Education,Culture,and Research(ACECR),Qom Branch,Qom,Iran [2]Infertility Treatment Center,Academic Center for Education,Culture,and Research(ACECR),Qom Branch,Qom,Iran [3]Cellular and Molecular Research Center,Qom University of Medical Sciences,Qom,Iran [4]Midwifery Ward,Infertility Treatment Center,Academic Center for Education,Culture,and Research(ACECR),Qom Branch,Qom,Iran

出　　处：《Reproductive and Developmental Medicine》2024年第2期89-92,共4页生殖与发育医学（英文版）

摘　　要：Objective:Duphaston is used as an alternative to gonadotropin-releasing hormone(GnRH)antagonists for suppressing premature luteinizing hormone(LH)surges.This study aimed to compare the efficacy of Duphaston protocols with that of Cetrotide in suppressing the LH surge.Methods:In this retrospective cross-sectional study,669 infertile women(aged 25-40 years)were administered recombinant follicle-stimulating hormone(rFSH)from the third day of their menstrual cycle.After the follicular diameter reached 13 to 14 mm,Cetrotide was prescribed orally to the control subjects,also case subjects took Duphaston orally.The retrieved oocytes were fertilized by an intracytoplasmic sperm injection(ICSI).Results:The levels of FSH,LH,and estradiol did not differ significantly between the groups(P>0.05).However,the findings indicated that Duphaston led to greater oocyte retrieval than Cetrotide(P=0.006).However,the number of mature oocytes and viable embryos in the case subjects did not reach a significant difference compared to that in the control subjects(P>0.05).The number of good-quality embryos(stage 1)was significantly higher in the case subjects(P=0.04).In addition,there is no significant difference in the chemical,clinical pregnancy,implantation rate,and miscarriage rate between both groups(P>0.05).Conclusion:Duphaston could be utilized as a suitable medication rather than a GnRH antagonist in women subjected to controlled ovarian hyperstimulation.

关 键 词：Duphaston Cetrotide Progesterone protocol Ovarian hyperstimulation GnRH antagonist 

分 类 号：R711.6[医药卫生—妇产科学]