白蛋白在胃肠外科围术期中的临床应用与研究进展  

Clinical application and research progress of albumin in the perioperative period of gastrointestinal surgery

作　　者：徐焕焕 赵婷[1] 朱贵伟 马文明[1] Xu Huanhuan;Zhao Ting;Zhu Guiwei;Ma Wenming(Clinical Pharmacy Department,Weifang People’s Hospital,Weifang 261041,China;Department of Critical Care Medicine,Weifang People’s Hospital,Weifang 261041,China)

机构地区：[1]潍坊市人民医院临床药学科,潍坊261041 [2]潍坊市人民医院重症医学科,潍坊261041

出　　处：《国际生物制品学杂志》2024年第3期181-185,共5页International Journal of Biologicals

基　　金：潍坊市科技发展计划(2022YX084);山东省第二批药品临床综合评价项目(2022YZ023)。

摘　　要：低白蛋白血症是腹部胃肠大手术预后不良的独立预测因子。为避免腹部术后低蛋白血症的发生, 人血清白蛋白在腹部术后并低白蛋白血症患者中的应用比较普遍。但是, 腹部术后应用人血清白蛋白是否具有临床获益, 目前尚存在争议。此文综述当前白蛋白在腹部围术期中的作用、病理生理变化、临床治疗获益以及营养价值等, 旨在加强临床医师对白蛋白的正确认识及合理应用, 以利于患者的术后管理, 降低用药费用。Hypoalbuminemia is an independent predictor of poor prognosis in major abdominal gastrointestinal surgery.To avoid the occurrence of hypoalbuminemia after abdominal surgery,the application of human serum albumin is relatively common in patients with hypoalbuminemia after abdominal surgery due to insufficient level of albumin.However,there is still controversy regarding the clinical benefits of using human serum albumin after abdominal surgery.This article reviews the current role,pathological and physiological changes,clinical treatment benefits,and nutritional value of albumin in the perioperative period of abdominal surgery,in order to strengthen clinical physicians’correct understanding and rational application of human albumin,in turn to facilitate postoperative management of patients and reduce medication costs.

关 键 词：低白蛋白血症 腹部胃肠大手术 人血清白蛋白 

分 类 号：R95[医药卫生—药学]