白藜芦醇保护血管内皮细胞的作用与机制  

Protective effect and mechanism of resveratrol on vascular endothelial cells

作　　者：杨扬 张红 刘振奎 赵自刚[1] Yang Yang;Zhang Hong;Liu Zhenkui;Zhao Zigang(Institute of Microcirculation,Hebei North University,Zhangjiakou 075000,Hebei,China;Department of Pediatrics,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei,China)

机构地区：[1]河北北方学院微循环研究所,河北张家口075000 [2]河北北方学院附属第一医院儿科,河北张家口075000

出　　处：《中华危重病急救医学》2024年第6期664-668,共5页Chinese Critical Care Medicine

基　　金：河北省中医药管理局科研计划项目(2017213)。

摘　　要：白藜芦醇是具有抗炎、抗氧化应激等多种生物活性的多酚类植物提取物。血管内皮细胞(VEC)是维持正常血管通透性、参与血管舒缩调节和物质交换的主要场所,VEC损伤在心血管疾病、慢性炎症、脓毒症等多种疾病或病理过程中发挥关键作用。研究表明,白藜芦醇通过调节一氧化氮(NO)及其相关酶、减轻氧化应激、抑制细胞凋亡等作用保护VEC,减轻内皮损伤,从而发挥良好的作用。Resveratrol is a polyphenolic plant extract with many biological activities such as anti-inflammation and anti-oxidative stress.Vascular endothelial cell(VEC)is the main sites for maintaining normal vascular permeability and participating in vasomotor regulation and substance exchange.VEC injury plays a key role in various diseases or pathological processes such as cardiovascular disease,chronic inflammation and sepsis.Studies have shown that resveratrol protects VEC and reduces endothelial damage by regulating nitric oxide(NO)and its related enzymes,reducing oxidative stress and inhibiting apoptosis,thereby exerting beneficial effects.

关 键 词：白藜芦醇 血管内皮细胞 一氧化氮 氧化应激 细胞凋亡 

分 类 号：R285[医药卫生—中药学]