离散元法(DEM)在中药固体制剂制造过程中的应用  

Application of discrete element method(DEM)in pharmaceutical process of solid traditional Chinese medicine preparations

作　　者：吴一峰 王子千 万鑫浩 胡恢权 杨怡琴 艾兵 杨明 伍振峰 WU Yi-feng;WANG Zi-qian;WAN Xin-hao;HU Hui-quan;YANG Yi-qin;AI Bing;YANG Ming;WU Zhen-feng(Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Jiangxi Technology Innovation Center of Green Manufacturing of Chinese Medicine,Nanchang 330004,China;National Key Laboratory of Creation of Modern Chinese Medicine with Classical Formulas,Nanchang 330004,China;Jiangxi Drug Inspection Center,Nanchang 330000,China)

机构地区：[1]江西中医药大学,现代中药制剂教育部重点实验室,江西南昌330004 [2]江西省中药绿色制造技术创新中心,江西南昌330004 [3]经典名方现代中药创制全国重点实验室,江西南昌330004 [4]江西省药品检查员中心,江西南昌330000

出　　处：《中国中药杂志》2024年第12期3152-3159,共8页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划项目(2023YFC3504500,2023YFC3504503)。

摘　　要：近年来,数值模拟越来越多地应用于新药研发和生产过程中,离散元法(DEM)是数值模拟方法中的一种重要方法,也是非连续介质模拟的有效手段。参考近年来DEM和中药固体制剂发展研究的相关进展,该文将对DEM在中药固体制剂制造过程中的应用进行总结分析,并在此基础上探讨其在中药固体制剂中应用存在的挑战,以期为推动中药制剂高质量制造提供新方法新思路。In recent years,the application of numerical simulation in the research and development(R&D)as well as the pharmaceutical processes of new drugs has expanded considerably.The discrete element method(DEM),an important approach among numerical simulation methods,offers an effective tool for the simulation of discontinuous media.Referring to the research progress of DEM and the formulation of solid traditional Chinese medicine(TCM)preparations in recent years,this paper summarizes and analyzes the application of DEM in the pharmaceutical processes of solid TCM preparations,and discusses the challenges of its application in these processes,in order to provide new methods and ideas for promoting the high-quality production of TCM preparations.

关 键 词：数值模拟 离散元法 中药固体制剂 制造过程 

分 类 号：R283.6[医药卫生—中药学]