植物端粒到端粒(T2T)基因组研究进展与展望  

Progress and Prospect of Plant Telomere-to-telomere(T2T)Genome

作　　者：宫少达 谢文召 赵如鹏 冯康宁 陈玲玲 GONG Shaoda;XIE Wenzhao;ZHAO Rupeng;FENG Kangning;CHEN Lingling(College of Life Science and Technology,Guangxi University,Nanning,530004;College of Informatics,Huazhong Agricultural University,Wuhan,430070)

机构地区：[1]广西大学生命科学与技术学院,南宁530004 [2]华中农业大学信息学院,武汉430070

出　　处：《基因组学与应用生物学》2024年第6期933-942,共10页Genomics and Applied Biology

基　　金：国家自然科学基金(32270712);广西科技重大专项(桂科AA23062085)共同资助。

摘　　要：高质量的参考基因组是基因组学研究的基础。目前,大多数的参考基因组仍然是不完整的。随着长读长测序技术的不断发展,完成端粒到端粒(telomere-to-telomere,T2T)基因组组装的物种越来越多。T2T基因组为深入研究着丝粒等复杂区域奠定了基础,对功能基因的挖掘和重要生物机制的研究具有重要意义。本文概述了植物T2T基因组的研究进展,结合实例介绍了相应的组装策略,讨论了T2T基因组的意义和面临的挑战,并对未来的发展前景进行了展望。The high-quality reference genome serves as the foundation for genomics research.Currently,the majority of reference genomes remain incomplete.With the continuous development of long-read sequencing technology,an increasing number of species have been successfully assembled telomere-to-telomere(T2T)genomes.The T2T genome lays the foundation for in-depth study of complex regions such as centromeres,and is of great significance for the excavation of functional genes and the study of important biological mechanisms.This paper provides an overview of the research progress on plant T2T genomes,presents the corresponding assembly strategies with examples,discusses the significance and challenges of T2T genomes,and offers a prospective view of future developments.

关 键 词：T2T基因组 测序技术 基因组组装 植物基因组 

分 类 号：Q943[生物学—植物学]