冠心病相关基因研究进展  

Research Progress on Genes Related to Coronary Heart Disease

作　　者：孙培雪 阮钰文 罗春艳 SUN Peixue;RUAN Yuwen;LUO Chunyan(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy,China Three Gorges University,Yichang,443002;Institute of Infection and Inflammation,College of Basic Medical Sciences,China Three Gorges University,Yichang,443002)

机构地区：[1]三峡大学肿瘤微环境与免疫治疗湖北省重点实验室,宜昌443002 [2]三峡大学基础医学院感染与炎症损伤研究所,宜昌443002

出　　处：《基因组学与应用生物学》2024年第6期958-966,共9页Genomics and Applied Biology

基　　金：国家自然科学基金(81900319)资助。

摘　　要：冠心病(coronary heart disease,CHD)是世界范围内致死率和致残率居首位的复杂性疾病。大量研究表明,冠心病是多个基因协同作用的,由遗传因素、环境因素或二者共同引发的表型呈间断分布的复杂性疾病。遗传因素显著影响冠心病的发生发展,其病理分子机制复杂,因此,对于冠心病易感基因的研究已经成为了深入了解冠心病发病机制的重要途径。本文综述了冠心病相关易感基因雄激素依赖性TFPI调节蛋白(androgen-dependent TFPI regulating protein,ADTRP)、载脂蛋白(apolipoprotein,Apo)基因家族、脂肪因子、炎症细胞因子等与冠心病发病机制之间的关联性。Coronary heart disease(CHD)is a complex disease with the highest mortality and disability rates worldwide.It is primarily caused by a combination of genetic and environmental factors,resulting in a diverse range of phenotypes.The genetic component signifi-cantly influences the development of coronary heart disease,and the pathological molecular mechanism is complex.It is crucial to understand the susceptibility genes linked to it in order to grasp its pathogenesis.This article offers an overview of the connection between different susceptibility genes,including androgen-dependent TFPI regulating protein(ADTRP),apolipoprotein(Apo)gene family,fat factor,inflammatory cytokine,and the progression of coronary heart disease.

关 键 词：冠心病 ADTRP 载脂蛋白 脂肪因子 炎症细胞因子 

分 类 号：R541.4[医药卫生—心血管疾病]