2018—2023年河北省手足口病病原构成及动态变化  

Pathogen spectrum and dynamic changes of hand,foot,and mouth disease in Hebei province from 2018 to 2023

作　　者：王昊冉 于秋丽[2] 刘莹莹[2] 赵文娜[2] 苏通[2] 陆辉 谢赟[2] 韩旭[2] 李琦[2] Wang Haoran;Yu Qiuli;Liu Yingying;Zhao Wenna;Su Tong;Lu Hui;Xie Yun;Han Xu;Li Qi(School of Public Health,North China University of Science and Technology,Tangshan 063200,China;Hebei Provincial Center for Disease Control and Prevention,Shijiazhuang 050024,China;Tangshan Municiple Center for Disease Control and Prevention,Tangshan 063000,China)

机构地区：[1]华北理工大学公共卫生学院,唐山063200 [2]河北省疾病预防控制中心病毒病防治所,石家庄050024 [3]唐山市疾病预防控制中心地方病防治所,063000

出　　处：《国际病毒学杂志》2024年第3期196-200,共5页International Journal of Virology

基　　金：河北省重大医学科研资助项目(zd2013068);河北省医学科学研究课题(20231181)。

摘　　要：目的掌握2018—2023年河北省手足口病病原构成;分析手足口病病原变化、变迁规律。方法采用描述流行病学的方法,阐述2018—2023年间河北省手足口病病原检出情况,分析河北省手足口病相关肠道病原的动态变迁规律,采用χ^(2)检验对不同人群、地区病原构成进行统计学分析。结果2018—2023年河北省手足口病年均发病率为27.22/10万,总体发病率呈隔年高发趋势;6年间累计检出手足口病阳性标本22142例,阳性检出率为76.09%,其中,CVA6检出最多,检出率为35.24%;HEV次之,检出率为20.35%;混合感染检出最少,检出率仅为0.17%。2018—2023年河北省手足口病优势病原不断变化,2018年优势病原为其他HEV,2019年优势病原为CVA16,2020—2023年优势病原为CVA6。其他职业组6年间CVA6构成比一直较高,EV-A71、CVA10和其他HEV的构成比明显低于散居儿童、幼托儿童和学生。6年间优势病原与总体不同的地区,2018年石家庄主要病原为CVA6,2019年承德、邯郸、唐山、邢台、张家口主要病原为其他HEV,衡水主要病原为CVA6,2020年邯郸、唐山主要病原为其他HEV,2021年廊坊主要病原为CVA16,2022年沧州、承德、唐山主要病原为其他HEV,邢台主要病原为CVA16。结论近年来CVA6成为河北省手足口病的绝对优势病原,不同人群中主要病原的变化趋势基本相似,其他次要病原构成和变化情况略有差异,部分地区优势病原为非EV-A71、CVA16、CVA6、CVA10的其他HEV,需要进一步细化肠道病毒分型工作,并对河北省手足口病病原进行长期广泛的监测,掌握其流行和变化规律。Objective To understand the pathogenic spectrum of hand,foot,and mouth disease(HFMD)in Hebei province from 2018 to 2023,and to analyze the pathogenic changes of HFMD.Methods The descriptive epidemiological method was used to describe the pathogen detection for HFMD in Hebei province from 2018 to 2023,and to analyze the dynamic changes of HFMD related enteroviruses in Hebei province.Chi-square test was used to analyze the spectrum of pathogens in different populations and regions.Results From 2018 to 2023,the average annual incidence rate of HFMD in Hebei province was 27.22/100000,and the overall incidence was high every two years.A total of 22142 positive samples of HFMD related enterovirus were detected,and the positive detection rate was 76.09%.CVA6 was the most detected,with a detection rate of 35.24%,followed by other HEVs,with a detection rate of 20.35%,and mixed infection was the least detected,with a detection rate of 0.17%.From 2018 to 2023,the dominant pathogen of HFMD in Hebei province continued to change.The dominant pathogen was other HEV in 2018,CVA16 in 2019,and CVA6 during 2020-2023.In other occupational groups,the constituent ratios of CVA6 were high during the six years,while the constituent ratios of EV-A71,CVA10 and other HEV were significantly lower than those in scattered children,children in child care facilities and students.There were some cities with different dominant pathogens during the six years.In 2018,the main pathogen was CVA6 in Shijiazhuang.In 2019,the main pathogen in Chengde,Handan,Tangshan,Xingtai and Zhangjiakou was other HEV and in Hengshui was CVA6.In 2020,the main pathogen was other HEV in Handan,Tangshan.In 2021,CVA16 was the main pathogen in Langfang.In 2022,CVA16 was the main pathogen in Cangzhou,Chengde and Tangshan,and CVA16 was the main pathogen in Xingtai.Conclusions In recent years,CVA6 has become the dominant pathogen of HFMD in Hebei province.The changes of major pathogens in different populations were basically similar,and the composition and changes of other mi

关 键 词：手足口病 肠道病毒 病原变迁 

分 类 号：R725.1[医药卫生—儿科] R181.3[医药卫生—临床医学]