2017—2021年通州区HIV筛查有反应样本抗体确证试验结果分析  

Confirmatory test result of HIV screening reactive samples in Tongzhou district of Beijing,2017-2021

作　　者：高洁 高翔[1] 周景林[1] 李震[2] 温祁 王芳[1] Gao Jie;Gao Xiang;Zhou Jinglin;Li Zhen;Wen Qi;Wang Fang(Central Laboratory,Tongzhou Center for Disease Prevention and Control,Beijing 101100,China;STD/AIDS Prevention and Treatment Department,Tongzhou Center for Disease Prevention and Control,Beijing 101100,China)

机构地区：[1]北京市通州区疾病预防控制中心中心实验室,101100 [2]北京市通州区疾病预防控制中心性病艾滋病防治所,101100

出　　处：《国际病毒学杂志》2024年第3期252-256,共5页International Journal of Virology

基　　金：通州区科技计划项目(KJ2022CX078)。

摘　　要：目的分析2017—2021年北京市通州区HIV筛查有反应样本抗体确证试验结果,了解通州区HIV抗体阳性病例分布特征,为艾滋病防控提供数据支撑。方法采用免疫印迹试验,对2017—2021年通州区HIV筛查有反应样本进行抗体确证试验,按照性别、年龄、送检机构、检测途径等类别进行结果分析。结果2017—2021年,通州区艾滋病确证实验室共接收HIV筛查有反应样本2480份,其中HIV-1抗体阳性994份(40.1%),HIV抗体不确定774份(31.2%),HIV抗体阴性712份(28.7%)。确证阳性率男性(51.6%)高于女性(8.6%)、20~39岁年龄组(44.4%)高于其他年龄组;阳性病例的感染途径主要为性传播(93.7%)。采供血机构确证阳性率最低(10.5%),疾病预防控制机构最高(91.8%);不同户籍、是否合并梅毒及不同检测途径样本阳性率差异均有统计学意义(P<0.05)。HIV筛查实验室(46.8%)与快检点(47.0%)确证阳性率差异无统计学意义。HIV-1抗体阳性样本WB结果以全条带为主(89.5%),不确定样本以单一条带为主(70.8%)。结论应进一步强化艾滋病防治宣传与扩大检测工作,加大不确定检测者随访力度,以推进HIV感染早发现、早治疗。Objective To review the HIV confirmatory test results for screening reactive samples in Tongzhou district of Beijing from 2017 to 2021 and understand the situation of HIV/AIDS epidemics in the district,so as to provide data support for HIV/AIDS prevention and control.Methods Western blot was used as the confirmatory test for HIV screening reactive samples in Tongzhou district from 2017 to 2021.The test results were analyzed according to gender,age,submitting institution,detection route and other categories.Results During 2017-2021,2480 samples were received in the confirmatory laboratory of Tongzhou district,including 994(40.1%)anti-HIV-1 antibody positive samples,774(31.2%)HIV indeterminate samples and 712(28.7%)negative samples.The confirmatory positive rate was higher in male(51.6%)than that in female(8.6%)and the rate in 20-39 years old group(44.4%)was higher than other age groups.The main route of infection among positive cases was sexual transmission(93.7%).The confirmatory positive rate of samples from blood center was the lowest(10.5%)while the samples from CDC had the highest rate(91.8%).The differences of confirmatory positive rates in residence registration,complication with syphilis and sample testing routes were statistically significant(P<0.05).The differences of confirmatory positive rates in screening laboratories(46.8%)and rapid detection points(47.0%)were not statistically significant.The most common WB band pattern in anti-HIV-1 antibody positive samples was presence of all bands(89.5%).The HIV indeterminate samples presented mainly single band(70.8%).Conclusions Strengthening further the propagation of HIV/AIDS prevention and control,expanding HIV antibody testing and increasing follow-up of HIV indeterminate persons would be necessary to promote the early detection and treatment of HIV infection.

关 键 词：艾滋病 人类免疫缺陷病毒 确证试验 免疫印迹法 

分 类 号：R512.91[医药卫生—内科学]