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作 者:伍玉丝 Wu Yushi(Department of Pharmacy,Yangshan Hospital of Traditional Chinese Medicine,Qingyuan 513100,China)
机构地区:[1]广东省阳山县中医院药剂科,广东清远513100
出 处:《糖尿病天地》2024年第5期21-23,共3页Diabetes World
摘 要:目的:评估厄贝沙坦+苯磺酸氨氯地平应用在老年糖尿病(DM)高血压(HT)合并高尿酸血症(HUA)患者中的疗效.方法:纳入2022年1月—2023年6月的150例老年DM合并HT伴HUA患者,遵循随机数表法分组,即:对照组(纳入75例,给予苯磺酸氨氯地平)、观察组(纳入75例,加用厄贝沙坦),评价组间糖代谢、血压、血尿酸、血清学指标、药品不良反应(ADR).结果:(1)治疗前,组间糖代谢[糖化血红蛋白(HbA1c)、空腹血糖(FPG)、餐后2h血糖(2hPG)]、血压[舒张压(DBP)、收缩压(SBP)]、血尿酸、血清学指标[C反应蛋白(CRP)、醛固酮(ALD)、血清C肽]无差异,P>0.05;治疗后,观察组糖代谢(HbA1c、FPG、2hPG)、血压(DBP、SBP)、血尿酸、血清学指标(CRP、ALD、血清C肽)更低,P<0.05;(2)在ADR方面,观察组(12.00%)与对照组(8.00%)无差异,P>0.05.结论:对老年DM合并HT伴HUA患者采用厄贝沙坦+苯磺酸氨氯地平,可以改善糖代谢,调节CRP、ALD、血清C肽水平,降低血压、血尿酸,加之安全性高,值得推广.Objective:To evaluate the efficacy of irbesartan+amlodipine besylate in elderly patients with diabetes mellitus(DM),hypertension(HT)and hyperuricemia(HUA).Methods:150 elderly DM patients with HT and HUA from January 2022 to June 2023 were included and grouped according to random number table method,namely:The control group(75 cases included,given amlodipine besylate)and the observation group(75 cases included,plus irbesartan)were evaluated for intergroup glucose metabolism,blood pressure,blood uric acid,serological indexes,and adverse drug reactions(ADR).Result:(1)Before treatment,there were no differences in glucose metabolism[HbAlc],fasting blood glucose(FPG),2h postmeal blood glucose[(2hPG)],blood pressure[DBP,SBP],serum uric acid,serological indices[CRP,ALD,C-peptide]between groups,P>0.05;After treatment,glucose metabolism(HbAlc,FPG,2hPG),blood pressure(DBP,SBP),blood uric acid,serological indexes(CRP,ALD,serum C-peptide)in observation group were lower,P<0.05;(2)In terms of ADR,there was no difference between observation group(12.00%)and control group(8.00%),P>0.05.Conclusion:The use of irbesartan+amlodipine besylate in elderly DM patients with HT and HUA can improve glucose metabolism,regulate CRP,ALD and serum C-peptide levels,reduce blood pressure and blood uric acid,and is safe and worthy of promotion.
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