厄贝沙坦联合苯磺酸氨氯地平治疗老年糖尿病高血压合并高尿酸血症患者的疗效分析  

Curative effect of Irbesartan combined with amlodipine besylate in the treatment of elderly patients with diabetic hypertension complicated with hyperuricemia

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作  者:伍玉丝 Wu Yushi(Department of Pharmacy,Yangshan Hospital of Traditional Chinese Medicine,Qingyuan 513100,China)

机构地区:[1]广东省阳山县中医院药剂科,广东清远513100

出  处:《糖尿病天地》2024年第5期21-23,共3页Diabetes World

摘  要:目的:评估厄贝沙坦+苯磺酸氨氯地平应用在老年糖尿病(DM)高血压(HT)合并高尿酸血症(HUA)患者中的疗效.方法:纳入2022年1月—2023年6月的150例老年DM合并HT伴HUA患者,遵循随机数表法分组,即:对照组(纳入75例,给予苯磺酸氨氯地平)、观察组(纳入75例,加用厄贝沙坦),评价组间糖代谢、血压、血尿酸、血清学指标、药品不良反应(ADR).结果:(1)治疗前,组间糖代谢[糖化血红蛋白(HbA1c)、空腹血糖(FPG)、餐后2h血糖(2hPG)]、血压[舒张压(DBP)、收缩压(SBP)]、血尿酸、血清学指标[C反应蛋白(CRP)、醛固酮(ALD)、血清C肽]无差异,P>0.05;治疗后,观察组糖代谢(HbA1c、FPG、2hPG)、血压(DBP、SBP)、血尿酸、血清学指标(CRP、ALD、血清C肽)更低,P<0.05;(2)在ADR方面,观察组(12.00%)与对照组(8.00%)无差异,P>0.05.结论:对老年DM合并HT伴HUA患者采用厄贝沙坦+苯磺酸氨氯地平,可以改善糖代谢,调节CRP、ALD、血清C肽水平,降低血压、血尿酸,加之安全性高,值得推广.Objective:To evaluate the efficacy of irbesartan+amlodipine besylate in elderly patients with diabetes mellitus(DM),hypertension(HT)and hyperuricemia(HUA).Methods:150 elderly DM patients with HT and HUA from January 2022 to June 2023 were included and grouped according to random number table method,namely:The control group(75 cases included,given amlodipine besylate)and the observation group(75 cases included,plus irbesartan)were evaluated for intergroup glucose metabolism,blood pressure,blood uric acid,serological indexes,and adverse drug reactions(ADR).Result:(1)Before treatment,there were no differences in glucose metabolism[HbAlc],fasting blood glucose(FPG),2h postmeal blood glucose[(2hPG)],blood pressure[DBP,SBP],serum uric acid,serological indices[CRP,ALD,C-peptide]between groups,P>0.05;After treatment,glucose metabolism(HbAlc,FPG,2hPG),blood pressure(DBP,SBP),blood uric acid,serological indexes(CRP,ALD,serum C-peptide)in observation group were lower,P<0.05;(2)In terms of ADR,there was no difference between observation group(12.00%)and control group(8.00%),P>0.05.Conclusion:The use of irbesartan+amlodipine besylate in elderly DM patients with HT and HUA can improve glucose metabolism,regulate CRP,ALD and serum C-peptide levels,reduce blood pressure and blood uric acid,and is safe and worthy of promotion.

关 键 词:厄贝沙坦 苯磺酸氨氯地平 老年 糖尿病 高血压 高尿酸血症 

分 类 号:R587.1[医药卫生—内分泌]

 

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