氢气的药理学作用及其给药途径的研究进展  

Advancements in pharmacological effects and administration routes of hydrogen gas:A comprehensive research overview

作　　者：张慧[1] 张红梅 彭军 凌云 Hui Zhang;Hongmei Zhang;Jun Peng;Yun Ling(Department of Pharmacy,Medical Supplies Center of Chinese PLA General Hospital,Beijing 100048,China;Department of Pharmacy,Hebei Yanda Hospital,Langfang 065201,Hebei,China)

机构地区：[1]解放军总医院医疗保障中心药剂科,北京100048 [2]河北燕达医院药学部,河北廊坊065201

出　　处：《Journal of Chinese Pharmaceutical Sciences》2024年第6期571-578,共8页中国药学（英文版）

摘　　要：氢气是自然界中含量最丰富的元素,是无色、无味、无臭的气体,具有很强的还原性。目前的研究证实,氢气具有抗氧化、抗疲劳、抗辐射、抗炎和降糖降脂的作用,可以治疗各种缺血再灌注损伤、器官移植损伤、神经变性疾病、动脉粥样硬化和代谢综合征等多种疾病。氢气在水中的溶解度极低,一个大气压下氢气的饱和浓度为只有0.8ppm,因此想要达到理想的氢气治疗浓度,就必须提高氢气的含量和提供合适的给药途径。氢气的给药方式有吸入法给氢、饮用富氢水、饱和氢生理盐水注射、增加体内氢气产生和口服固体释氢药物等。本文总结了氢气的药理学作用及其给药途径,为氢气在治疗应用上提供思路。Hydrogen,the simplest element in the universe.Hydrogen gas is colorless,odorless,and tasteless.As a reducing agent composed of two atoms.It exhibits strong reducing power and possesses numerous pharmacological effects,including anti-oxidation,antifatigue,anti-radiation,anti-inflammation,hypoglycemic,and hypolipidemic effects.Various methods exist for supplying hydrogen,but inhaling the gas is dangerous,drinking hydrogen-rich water is ineffective,and injecting hydrogen-rich saline is inconvenient.The most viable approach for clinical use is oral medicine,which produces hydrogen in vivo.Hydrogen gas holds promising potential as a clinical medicine in the future.

关 键 词：氢气 药理作用 给药途径 研究进展 

分 类 号：R962[医药卫生—药理学]