Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp^(3))and C(sp)-C(sp^(2))bonds  

作　　者：Lei Wan Yizhou Tong Xi Lu Yao Fu 

机构地区：[1]Hefei National Research Center for Physical Sciences at the Microscale,iChEM,CAS Key Laboratory of Urban Pollutant Conversion,Anhui Province Key Laboratory of Biomass Clean Energy,University of Science and Technology of China,Hefei 230026,China [2]Key Laboratory of Precision and Intelligent Chemistry,School of Chemistry and Materials Science,University of Science and Technology of China,Hefei 230026,China

出　　处：《Chinese Chemical Letters》2024年第7期253-258,共6页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22371273,22293011 and T2341001);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(No.2023476);the National Science Foundation of Anhui Province(No.2208085J26)。

摘　　要：Transition-metal-catalyzed cross-electrophile coupling has emerged as a reliable method for constructing carbon–carbon bonds.Herein,we report a general method,cobalt-catalyzed reductive alkynylation,to construct C(sp)-C(sp^(3))and C(sp)-C(sp^(2))bonds.This presented reaction has a broad substrate scope,enabling the efficient cross-electrophile coupling between alkynyl bromides with alkyl halides and aryl or alkenyl(pseudo)halides.This presented reaction is conducted under mild conditions,tolerating many functional groups,thus suitable for the modification and synthesis of biologically active molecules.

关 键 词：Cobalt-catalysis Cross-electrophile coupling Carbon-carbon bond formation Reductive alkynylation Alkyne synthesis 

分 类 号：O621.251[理学—有机化学]