Base-controlled NHC-Ru-catalyzed transfer hydrogenation andα-methylation/transfer hydrogenation of ketones using methanol  

作　　者：Ming Huang Xiuju Cai Yan Liu Zhuofeng Ke 

机构地区：[1]School of pharmacy,School of clinical pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China [2]School of Materials Science&Engineering,PCFM Lab,School of Chemistry,Sun Yat-sen University,Guangzhou 510275,China [3]School of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006,China

出　　处：《Chinese Chemical Letters》2024年第7期276-280,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(NSFC,Nos.22002023,21973113,21977019);the Guangdong Natural Science Funds for Distin-guished Young Scholar(No.2015A030306027);the Tip-top Youth Talents of Guangdong special support program(No.20153100042090537);the Fundamental Research Funds for the Central Universities。

摘　　要：Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with methanol.By simply changing the base,a broad range of structurally diverse ketones,could be selectively and efficiently converted to the correspondingβ-methylated secondary alcohols or secondary alcohols.Remarkably,this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols,as well as the three-component coupling between methyl ketones,primary alcohols,and methanol.The reaction mechanism was further revealed by experiment and DFT mechanistic investigations.

关 键 词：Ru complexes METHANOL KETONES β-Methylated secondary alcohols Transfer hydrogenation 

分 类 号：O621.251[理学—有机化学]