2-喹啉-3-苯基喹诺酮衍生物的电化学合成研究  

Electrochemical Synthesis of 2-quinoline-3-phenyl Quinolone Derivatives

作　　者：刘迎春 胡洋洋 张佳慧 冉亚楠 李美锦 李梦蕊 刘磊[1] LIU Yingchun;HU Yangyang;ZHANG Jiahui;RAN Ya’nan;LI Meijin;LI Mengrui;LIU Lei(College of pharmacy,Qiqihar Medical University,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔医学院药学院,黑龙江齐齐哈尔161006

出　　处：《化工管理》2024年第20期76-80,共5页Chemical Management

基　　金：齐齐哈尔医学院大学生创新创业训练计划项目(x202311230002)。

摘　　要：喹诺酮类结构是一种重要的有机含氮杂环,普遍存在于天然活性产物及药物结构中,具有许多药理活性。文章采用电化学合成方法,在温和的条件下以1-(2-氨基苯基)-2-苯基乙烷-1-酮和二甲基喹啉为原料,通过电化学诱导合成2-喹啉-3-苯基喹诺酮衍生物,并用核磁共振氢谱、核磁共振碳谱和质谱对其结构进行表征。实验结果证明,该方法收率较高,产物的原材料易获取,为合成2-喹啉-3-苯基喹诺酮类结构提供了一种独特的方案。Quinolones as an important organic nitrogen-containing heterocycle,are widely found in natural active products and drug structures,and have many pharmacological activities.article,the electrochemical synthesis of 1-(2-aminophenyl)-2-phenylethane-1-one and dimethyl quinoline was studied under mild conditions.2-quinoline-3-phenylquinolone derivatives were synthesized by electrochemical redox and characterized by Proton 1HNMR,13CNMR and HRMS.The experimental results demonstrate that the method yields high results,and the raw materials for the product are easily obtainable.This offers a distinctive approach for the synthesis of 2-quinoline-3-phenyl quinolones.

关 键 词：喹诺酮 电化学合成 二甲基喹啉 1-(2-氨基苯基)-2-苯基乙烷-1-酮 

分 类 号：O622[理学—有机化学]