拟除虫菊酯类农药暴露的免疫毒理学研究进展  

Research Progress on Immunotoxicology of Pyrethroid Pesticides Exposures

作　　者：齐志业[1,2,3] 陈颖 李燕 QI Zhiye;CHEN Ying;LI Yan(Dept.of Pediatrics,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032;Children’s Medical Center,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032;School of Public Health,Kunming Medical University,Kunming Yunnan 650500;Chongqing Yuzhong District Center For Disease Control And Prevention,Chongqing 400010,China)

机构地区：[1]昆明医科大学第一附属医院儿内科,云南昆明650032 [2]昆明医科大学第一附属医院儿童医学中心,云南昆明650032 [3]昆明医科大学公共卫生学院,云南昆明650500 [4]重庆市渝中区疾病预防控制中心,重庆400010

出　　处：《昆明医科大学学报》2024年第8期154-160,共7页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(82160621);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202101AY070001-099)。

摘　　要：免疫功能是人体的重要生理功能,在维持人类健康中起着至关重要的作用。拟除虫菊酯类农药(pyrethroid pesticides, PYRs)及其代谢产物可对机体产生免疫毒性,导致免疫相关疾病的患病风险增加。通过对PYRs暴露对机体免疫器官、免疫细胞和免疫分子的影响及其免疫毒理学机制进行综述,并对生命早期PYRs暴露所致机体免疫毒性进行总结和展望,为人类PYRs暴露的免疫毒理学研究提供新的思路和建议。Immune function is an important physiological function in the human body that plays a crucial role in maintaining human health.Pyrethroid pesticides(PYRs)and their metabolites can have immunotoxic effects on the body,increasing the risk of immune-related diseases.This review summarizes the effects of PYRs exposure on the body’simmune organs,immune cells,and immune molecules,as well as the immunotoxic mechanisms,and provides a summary and outlook on the immunotoxicity caused by early-life PYRs exposure,offering new ideas and recommendations for human studies on the immunotoxicity of PYRs exposure.

关 键 词：拟除虫菊酯 农药 免疫功能 免疫毒理学 

分 类 号：R114[医药卫生—卫生毒理学]