陕西省汉中市1~6岁儿童血清维生素D水平调查及影响因素分析  

Investigation of Serum Vitamin D Levels and Analysis of Related Factors in Children Aged 1~6 in Hanzhong City of Shaanxi

作　　者：乔永峰 胡健[1] 马燕粉[1] 王晓琴[1] QIAO Yongfeng;HU Jian;MA Yanfen;WANG Xiaoqin(Department of Clinical Laboratory,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China;Department of Clinical Laboratory,Hanzhong Central Hospital,Shaanxi Hanzhong 723000,China)

机构地区：[1]西安交通大学第一附属医院检验科,西安710061 [2]汉中市中心医院检验科,陕西汉中723000

出　　处：《现代检验医学杂志》2024年第4期83-87,共5页Journal of Modern Laboratory Medicine

摘　　要：目的调查陕西省汉中市儿童血清维生素D水平及其分布状态,为预防儿童维生素D缺乏提供依据。方法选取汉中市中心医院儿童保健门诊2019年3月~2021年2月6780例1~6岁体检儿童为研究对象,采用液相色谱串联质谱(liquid chromatography-tandem mass spectrometry,LC-MS/MS)法检测血清25羟基维生素D[25-hydroxyvitamin D,25(OH)D],25羟基维生素D_(2)[25-hydroxyvitamin D_(2),25(OH)D_(2)]和25羟基维生素D_(3)[25-hydroxyvitamin D_(3),25(OH)D_(3)]水平,并分析不同年龄、性别、季节间差异。结果儿童总体血清25(OH)D,25(OH)D_(2),25(OH)D_(3)水平分别为38.24±9.84 ng/ml,2.31±3.91 ng/ml和35.93±9.93 ng/ml。维生素D缺乏率为2.74%(186/6780),不足率为18.29%(1240/6780),充足率为78.97%(5354/6780)。1~2岁、2~3岁和3~6岁儿童血清25(OH)D和25(OH)D_(3)水平随年龄增长而逐渐降低,维生素D缺乏率增加,差异具有统计学意义(F=1153.499,1165.341,1374.051,均P<0.05)。不同性别儿童血清25(OH)D,25(OH)D_(2),25(OH)D_(3)水平和维生素D营养分布状态比较,差异均无统计学意义(t/χ^(2)=0.727,1.271,0.222,2.659,均P>0.05)。冬季儿童血清25(OH)D和25(OH)D_(3)水平均低于春、夏、秋季,差异具有统计学意义(q=6.853,7.281,6.801;5.341,6.225,5.989,均P<0.01);维生素D缺乏率高于春、夏、秋季(6.60%vs 2.64%,1.91%,1.66%),差异具有统计学意义(χ^(2)=31.733,52.252,57.756,均P<0.01)。结论汉中市3~6岁儿童普遍存在维生素D缺乏或不足,应加强冬季户外活动,鼓励血清维生素D水平监测,必要时补充维生素D。Objective To survey the levels and distributed status of serum vitamin D in children in Hanzhong city of Shaanxi,and provide a basis for the prevention of children with vitamin D deficiency.Methods A total of 6780 children aged 1 to 6 years from March 2019 to February 2021 in Children’s Health Clinic of Hanzhong Center Hospital for physical examination were selected as subjects.The levels of serum 25-hydroxyvitamin D[25(OH)D],serum 25-hydroxyvitamin D_(2)[25(OH)D_(2)]and serum 25-hydroxyvitamin D_(3)[25(OH)D_(3)]were measured by liquid chromatography-tandem mass spectrometry(LC-MS/MS),and the factors of ages and sexes and seasons were analyzed.Results The levels of serum 25(OH)D,25(OH)D_(2) and 25(OH)D_(3) in all children were 38.24±9.84 ng/ml,2.31±3.91 ng/ml and 35.93±9.93 ng/ml,respectively.The vitamin D deficiency rate,insufficiency rate and adequacy rate were 2.75%(186/6780),18.29%(1240/6780)and 78.96%(5354/6780),respectively.The levels of serum 25(OH)D and 25(OH)D_(3) in children aged 1~2,2~3 and 3~6 years were gradually decreased with the growth of age,while the rate of vitamin D deficiency was increased,with significant differences(F=1153.499,1165.341,1374.051,all P<0.05).There were no significant differences in distributed status of serum of vitamin D and the levels of serum 25(OH)D,25(OH)D_(2) and 25(OH)D_(3) levels among different genders(t/χ^(2)=0.727,1.271,0.222,2.659,all P>0.05).The levels of serum 25(OH)D and 25(OH)D_(3) in winter were lower than those in spring,summer and autumn,and the differences were statistically significant(q=6.853,7.281,6.801;5.341,6.225,5.989,all P<0.01).The vitamin D deficiency rate in winter was higher than that in spring,summer and autumn(6.60%,2.64%,1.91%,1.66%).and the differences were statistically significant(χ^(2)=31.733,52.252,57.756,all P<0.01).Conclusion A high incidence of vitamin D deficiency or insufficiency was found in children aged 3 to 6 in Hanzhong city.It was necessary to strengthen outdoor activities in winter,encourage monitoring of serum vitamin

关 键 词：儿童 维生素D 血清25羟维生素D 液相色谱串联质谱 汉中地区 

分 类 号：R446.112[医药卫生—诊断学]